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Article

Antimicrobial Efficacy of an Ultraviolet-C Device against Microorganisms Related to Contact Lens Adverse Events

Optometry School, College of Health and Life Sciences, Aston University, Birmingham B4 7ET, UK
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Author to whom correspondence should be addressed.
Academic Editor: Marc Maresca
Antibiotics 2022, 11(5), 699; https://doi.org/10.3390/antibiotics11050699
Received: 25 March 2022 / Revised: 16 May 2022 / Accepted: 19 May 2022 / Published: 21 May 2022
(This article belongs to the Special Issue Ocular Surface Infection and Antimicrobials)
The purpose of the study was to assess the antimicrobial activity of an ultraviolet-C (UVC) device against microorganisms implicated in contact lens related adverse events. An UVC device with an emitting 4.5 mm diameter Light Emitting Diode (LED; 265 nm; 1.93 mJ/cm2) was used. Pseudomonas aeruginosa, Staphylococcus aureus, Fusarium solani, and Candida albicans agar plate lawns were exposed to the device beams for 15 and 30 s at 8 mm distance. Following the exposure, the diameter of the growth inhibition zone was recorded. Contact lenses made of Delfilicon-A, Senofilicon-A, Comfilicon-A, Balafilicon-A, Samfilicon-A and Omafilicon-A and a commercially available contact storage case was used. They were exposed to bacterial and fungal strains for 18 h at 37 °C and 25 °C respectively. After this, the samples were exposed to UVC for 30 s at 8 mm distance to determine the antimicrobial efficacy. Samples were then gently washed and plated on appropriate agar for enumeration of colonies. The UVC exposure reduced microbial growth by 100% in agar lawns, and significantly (p < 0.05) reduced microbial contamination to contact lenses and cases, ranging between 0.90 to 4.6 log. Very short UVC exposure has high antimicrobial efficacy against most of the predominant causative microorganisms implicated in contact lens related keratitis. UVC could be readily used as a broad-spectrum antimicrobial treatment for lens disinfection. View Full-Text
Keywords: contact lenses; ultraviolet C; keratitis; Pseudomonas; Staphylococcus; Fusarium; Candida; antibiotic resistance contact lenses; ultraviolet C; keratitis; Pseudomonas; Staphylococcus; Fusarium; Candida; antibiotic resistance
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MDPI and ACS Style

Dumpati, S.; Naroo, S.A.; Shah, S.; Dutta, D. Antimicrobial Efficacy of an Ultraviolet-C Device against Microorganisms Related to Contact Lens Adverse Events. Antibiotics 2022, 11, 699. https://doi.org/10.3390/antibiotics11050699

AMA Style

Dumpati S, Naroo SA, Shah S, Dutta D. Antimicrobial Efficacy of an Ultraviolet-C Device against Microorganisms Related to Contact Lens Adverse Events. Antibiotics. 2022; 11(5):699. https://doi.org/10.3390/antibiotics11050699

Chicago/Turabian Style

Dumpati, Srikanth, Shehzad A. Naroo, Sunil Shah, and Debarun Dutta. 2022. "Antimicrobial Efficacy of an Ultraviolet-C Device against Microorganisms Related to Contact Lens Adverse Events" Antibiotics 11, no. 5: 699. https://doi.org/10.3390/antibiotics11050699

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