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Article

Occurrence of Multi-Drug-Resistant Escherichia coli in Chickens, Humans, Rodents and Household Soil in Karatu, Northern Tanzania

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Africa Centre of Excellence for Innovative Rodent Pest Management and Biosensor Technology Development (ACE IRPM & BTD), Sokoine University of Agriculture, P.O. Box 3110, Morogoro 67125, Tanzania
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Department of Wildlife Management, College of Forestry, Wildlife and Tourism, P.O. Box 3073, Morogoro 67125, Tanzania
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Livestock Training Agency (LITA), Buhuri Campus, P.O. Box 1483, Tanga 21206, Tanzania
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Institute of Pest Management, Sokoine University of Agriculture, P.O. Box 3110, Morogoro 67125, Tanzania
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Department of Veterinary Microbiology, Parasitology and Biotechnology, College of Veterinary Medicine and Biomedical Sciences, Sokoine University of Agriculture, P.O. Box 3019, Morogoro 67125, Tanzania
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Department of Microbiology and Immunology, School of Medicine, Muhimbili University of Health and Allied Sciences, P.O. Box 65001, Dar es Salaam 11103, Tanzania
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Author to whom correspondence should be addressed.
Academic Editor: William R. Schwan
Antibiotics 2021, 10(9), 1137; https://doi.org/10.3390/antibiotics10091137
Received: 9 July 2021 / Revised: 12 September 2021 / Accepted: 13 September 2021 / Published: 21 September 2021
We investigated antibiotic resistance profiles of Escherichia coli among 960 samples obtained from chickens (236), humans (243), rodents (101) and soil (290). E. coli was isolated from 650 (67.7%) samples. Isolation frequency varied significantly between chickens, humans, rodents and soil samples, being 81.6%, 86.5%, 79.2% and 31.0%, respectively (p < 0.001). Resistance rates were particularly higher against imipenem (79.8%), cefotaxime (79.7%) and tetracycline (73.7%) and moderate against amoxicillin-clavulanate (49.4%). Overall, 78.8% of the isolates were multidrug-resistant (MDR) among which, 38.8%, 25.1%, 12.9% and 2.5% exhibited resistance to three, four, five and six different classes of antibiotics, respectively. Multidrug-resistant E. coli were observed in 27.7%, 30.3%, 10.8% and 10.0% of the isolates from chickens, humans, rodents and soil samples, respectively. Our results show high levels of antimicrobial resistance including MDR in E. coli isolated from chickens, humans, rodents and soil samples in Karatu, Northern Tanzania. Comprehensive interventions using a one-health approach are needed and should include improving (i) awareness of the community on judicious use of antimicrobial agents in humans and animals, (ii) house conditions and waste management and (iii) rodent control measures. View Full-Text
Keywords: Escherichia coli; antibiotic resistance; humans; rodents; chickens; soil; isolates Escherichia coli; antibiotic resistance; humans; rodents; chickens; soil; isolates
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MDPI and ACS Style

Sonola, V.S.; Katakweba, A.S.; Misinzo, G.; Matee, M.I.N. Occurrence of Multi-Drug-Resistant Escherichia coli in Chickens, Humans, Rodents and Household Soil in Karatu, Northern Tanzania. Antibiotics 2021, 10, 1137. https://doi.org/10.3390/antibiotics10091137

AMA Style

Sonola VS, Katakweba AS, Misinzo G, Matee MIN. Occurrence of Multi-Drug-Resistant Escherichia coli in Chickens, Humans, Rodents and Household Soil in Karatu, Northern Tanzania. Antibiotics. 2021; 10(9):1137. https://doi.org/10.3390/antibiotics10091137

Chicago/Turabian Style

Sonola, Valery S., Abdul S. Katakweba, Gerald Misinzo, and Mecky I.N. Matee 2021. "Occurrence of Multi-Drug-Resistant Escherichia coli in Chickens, Humans, Rodents and Household Soil in Karatu, Northern Tanzania" Antibiotics 10, no. 9: 1137. https://doi.org/10.3390/antibiotics10091137

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