Prevalence and Impact of Biofilms on Bloodstream and Urinary Tract Infections: A Systematic Review and Meta-Analysis
Abstract
1. Introduction
2. Results and Discussion
2.1. Bloodstream Infections
2.1.1. Literature Search and Study Selection
2.1.2. Study Characteristics
2.1.3. BFP Unrelated Prevalence: Single-Armed Meta-Analysis
2.1.4. BFP Prevalence Related to Resistance: Two-Armed Meta-Analysis
2.1.5. BFP Prevalence Related to Persistence: Two-Armed Meta-Analysis
2.1.6. BFP Prevalence Related to Mortality: Two-Armed Meta-Analysis
2.2. Urinary Tract Infections
2.2.1. Literature Search and Study Selection
2.2.2. Study Characteristics
2.2.3. BFP Unrelated Prevalence: Single-Armed Meta-Analysis
2.2.4. BFP Prevalence Related to Resistance: Two-Armed Meta-Analysis
2.2.5. BFP Prevalence Related to CAUTI: Two-Armed Meta-Analysis
3. Materials and Methods
3.1. Literature Search
3.2. Study Selection
3.3. Data Extraction
3.4. Data Analysis
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Inclusion Criteria |
---|
- Observational study and original research |
- Only Human BSI/bacteremia/fungemia/sepsis clinical isolates (BSI); Only Human UTI clinical isolates (UTI) |
- Minimum of 15 clinical isolates (sample size) |
- Isolates from blood cultures and/or catheter tips (BSI); Isolates from urine or catheters (UTI) |
- Reports on biofilm in vitro production prevalence |
- Reports on biofilm in vitro production prevalence related to clinical outcomes or to resistant vs. susceptible strains |
- Healthcare settings (BSI); Healthcare settings (outpatients and inpatients) (UTI) |
- In vitro biofilm production/detection only |
- Crystal violet/safranin assay and on microtiter/tissue culture plates for biofilm production/detection * |
- Biofilm formation in 24 h * |
- Results in categorical data (Optical density (OD) cut-offs) |
- OD cut-offs for negative/positive biofilm production * |
- Studies published in English, French or Portuguese and from 1 January 2005 |
Exclusion Criteria |
- Contaminant isolates |
- Results in OD mean values |
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Pinto, H.; Simões, M.; Borges, A. Prevalence and Impact of Biofilms on Bloodstream and Urinary Tract Infections: A Systematic Review and Meta-Analysis. Antibiotics 2021, 10, 825. https://doi.org/10.3390/antibiotics10070825
Pinto H, Simões M, Borges A. Prevalence and Impact of Biofilms on Bloodstream and Urinary Tract Infections: A Systematic Review and Meta-Analysis. Antibiotics. 2021; 10(7):825. https://doi.org/10.3390/antibiotics10070825
Chicago/Turabian StylePinto, Henrique, Manuel Simões, and Anabela Borges. 2021. "Prevalence and Impact of Biofilms on Bloodstream and Urinary Tract Infections: A Systematic Review and Meta-Analysis" Antibiotics 10, no. 7: 825. https://doi.org/10.3390/antibiotics10070825
APA StylePinto, H., Simões, M., & Borges, A. (2021). Prevalence and Impact of Biofilms on Bloodstream and Urinary Tract Infections: A Systematic Review and Meta-Analysis. Antibiotics, 10(7), 825. https://doi.org/10.3390/antibiotics10070825