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Review

The Potential Role of Bacteriophages in the Treatment of Recalcitrant Chronic Rhinosinusitis

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Department of Otorhinolaryngology, UZ Leuven, 3000 Leuven, Belgium
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Department of Neurosciences, Experimental Otorhinolaryngology, Rhinology Research, KU Leuven, 3000 Leuven, Belgium
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Department of Trauma Surgery, UZ Leuven, 3000 Leuven, Belgium
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Department of Development and Regeneration, Locomotor and Neurological Disorders, KU Leuven, 3000 Leuven, Belgium
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Department of Pneumology, UZ Leuven, 3000 Leuven, Belgium
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Department of Chronic Diseases and Metabolism, Respiratory Diseases and Thoracic Surgery, KU Leuven, 3000 Leuven, Belgium
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Pharmacy Department, UZ Leuven, 3000 Leuven, Belgium
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Department of Biosystems, Laboratory of Gene Technology, KU Leuven, 3000 Leuven, Belgium
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Department of Pharmaceutical and Pharmacological Sciences, Clinical Pharmacology and Pharmacotherapy, KU Leuven, 3000 Leuven, Belgium
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Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Unit, KU Leuven, 3000 Leuven, Belgium
*
Author to whom correspondence should be addressed.
Academic Editors: Bożena Nejman-Faleńczyk and Sylwia Bloch
Antibiotics 2021, 10(6), 675; https://doi.org/10.3390/antibiotics10060675
Received: 30 April 2021 / Revised: 26 May 2021 / Accepted: 2 June 2021 / Published: 5 June 2021
Chronic rhinosinusitis is a common condition affecting 5–12% of the general population worldwide. In a limited number of cases, the disease is recalcitrant to medical and surgical interventions, causing a major impact on physical, social and emotional well-being and increasing pressure on healthcare systems. Biofilm formation and dysbiosis caused by Staphylococcus aureus and Pseudomonas aeruginosa play a role in the pathogenesis of recalcitrant chronic rhinosinusitis. In these cases, a promising treatment alternative is the application of bacteriophages, which are viruses that infect and lyse bacteria. In this review, we appraise the evidence for the use of bacteriophages in the treatment of recalcitrant chronic rhinosinusitis. Additionally, (dis)advantages of bacteriophages and considerations for implementation of phage therapy in otorhinolaryngology practice will be discussed. View Full-Text
Keywords: chronic rhinosinusitis; recalcitrant; refractory; therapy-resistant; bacteriophages; phages; endolysins; phage therapy chronic rhinosinusitis; recalcitrant; refractory; therapy-resistant; bacteriophages; phages; endolysins; phage therapy
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MDPI and ACS Style

Uyttebroek, S.; Onsea, J.; Metsemakers, W.-J.; Dupont, L.; Devolder, D.; Wagemans, J.; Lavigne, R.; Spriet, I.; Van Gerven, L. The Potential Role of Bacteriophages in the Treatment of Recalcitrant Chronic Rhinosinusitis. Antibiotics 2021, 10, 675. https://doi.org/10.3390/antibiotics10060675

AMA Style

Uyttebroek S, Onsea J, Metsemakers W-J, Dupont L, Devolder D, Wagemans J, Lavigne R, Spriet I, Van Gerven L. The Potential Role of Bacteriophages in the Treatment of Recalcitrant Chronic Rhinosinusitis. Antibiotics. 2021; 10(6):675. https://doi.org/10.3390/antibiotics10060675

Chicago/Turabian Style

Uyttebroek, Saartje, Jolien Onsea, Willem-Jan Metsemakers, Lieven Dupont, David Devolder, Jeroen Wagemans, Rob Lavigne, Isabel Spriet, and Laura Van Gerven. 2021. "The Potential Role of Bacteriophages in the Treatment of Recalcitrant Chronic Rhinosinusitis" Antibiotics 10, no. 6: 675. https://doi.org/10.3390/antibiotics10060675

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