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Bacteriophage-Derived Depolymerases against Bacterial Biofilm

Department of Molecular Biology, Faculty of Biology, University of Gdańsk, Wita Stwosza 59, 80-308 Gdańsk, Poland
Laboratory of Phage Therapy, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Kładki 24, 80-822 Gdańsk, Poland
Author to whom correspondence should be addressed.
Academic Editor: Adelaide Almeida
Antibiotics 2021, 10(2), 175;
Received: 28 December 2020 / Revised: 3 February 2021 / Accepted: 6 February 2021 / Published: 10 February 2021
In addition to specific antibiotic resistance, the formation of bacterial biofilm causes another level of complications in attempts to eradicate pathogenic or harmful bacteria, including difficult penetration of drugs through biofilm structures to bacterial cells, impairment of immunological response of the host, and accumulation of various bioactive compounds (enzymes and others) affecting host physiology and changing local pH values, which further influence various biological functions. In this review article, we provide an overview on the formation of bacterial biofilm and its properties, and then we focus on the possible use of phage-derived depolymerases to combat bacterial cells included in this complex structure. On the basis of the literature review, we conclude that, although these bacteriophage-encoded enzymes may be effective in destroying specific compounds involved in the formation of biofilm, they are rarely sufficient to eradicate all bacterial cells. Nevertheless, a combined therapy, employing depolymerases together with antibiotics and/or other antibacterial agents or factors, may provide an effective approach to treat infections caused by bacteria able to form biofilms. View Full-Text
Keywords: bacterial biofilm; bacteriophages; phage-encoded depolymerases; combined therapy bacterial biofilm; bacteriophages; phage-encoded depolymerases; combined therapy
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MDPI and ACS Style

Topka-Bielecka, G.; Dydecka, A.; Necel, A.; Bloch, S.; Nejman-Faleńczyk, B.; Węgrzyn, G.; Węgrzyn, A. Bacteriophage-Derived Depolymerases against Bacterial Biofilm. Antibiotics 2021, 10, 175.

AMA Style

Topka-Bielecka G, Dydecka A, Necel A, Bloch S, Nejman-Faleńczyk B, Węgrzyn G, Węgrzyn A. Bacteriophage-Derived Depolymerases against Bacterial Biofilm. Antibiotics. 2021; 10(2):175.

Chicago/Turabian Style

Topka-Bielecka, Gracja, Aleksandra Dydecka, Agnieszka Necel, Sylwia Bloch, Bożena Nejman-Faleńczyk, Grzegorz Węgrzyn, and Alicja Węgrzyn. 2021. "Bacteriophage-Derived Depolymerases against Bacterial Biofilm" Antibiotics 10, no. 2: 175.

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