Sorting out the Superbugs: Potential of Sortase A Inhibitors among Other Antimicrobial Strategies to Tackle the Problem of Antibiotic Resistance
Abstract
:1. Introduction
2. The Emergence of Antibiotic-Resistant Gram-Positive Pathogens of Healthcare Importance
3. Alternative Options
3.1. Phage Therapy
3.2. Lysins
3.3. Antimicrobial Peptides
3.4. Bacteriocins
3.5. Antivirulence Strategies
4. Sortase A (SrtA)
5. SrtA Inhibitors
6. Materials and Methods
6.1. SrtA Expression and Purification
6.2. FRET Enzymatic Assay and IC50 Determination
7. Conclusions
Supplementary Materials
Author Contributions
Funding
Data Availability Statement
Conflicts of Interest
References
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Zrelovs, N.; Kurbatska, V.; Rudevica, Z.; Leonchiks, A.; Fridmanis, D. Sorting out the Superbugs: Potential of Sortase A Inhibitors among Other Antimicrobial Strategies to Tackle the Problem of Antibiotic Resistance. Antibiotics 2021, 10, 164. https://doi.org/10.3390/antibiotics10020164
Zrelovs N, Kurbatska V, Rudevica Z, Leonchiks A, Fridmanis D. Sorting out the Superbugs: Potential of Sortase A Inhibitors among Other Antimicrobial Strategies to Tackle the Problem of Antibiotic Resistance. Antibiotics. 2021; 10(2):164. https://doi.org/10.3390/antibiotics10020164
Chicago/Turabian StyleZrelovs, Nikita, Viktorija Kurbatska, Zhanna Rudevica, Ainars Leonchiks, and Davids Fridmanis. 2021. "Sorting out the Superbugs: Potential of Sortase A Inhibitors among Other Antimicrobial Strategies to Tackle the Problem of Antibiotic Resistance" Antibiotics 10, no. 2: 164. https://doi.org/10.3390/antibiotics10020164