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Article

Bioactive Coatings Based on Hydroxyapatite, Kanamycin, and Growth Factor for Biofilm Modulation

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Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, 011061 Bucharest, Romania
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Lasers Department, National Institute for Lasers, Plasma and Radiation Physics, 077125 Magurele, Romania
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Research Institute of the University of Bucharest–ICUB, University of Bucharest, 050657 Bucharest, Romania
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Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 050095 Bucharest, Romania
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Department of Microbiology and Immunology, Faculty of Biology, University of Bucharest, 077206 Bucharest, Romania
*
Author to whom correspondence should be addressed.
Academic Editor: Thomas D. Michl
Antibiotics 2021, 10(2), 160; https://doi.org/10.3390/antibiotics10020160
Received: 31 December 2020 / Revised: 22 January 2021 / Accepted: 2 February 2021 / Published: 5 February 2021
(This article belongs to the Special Issue Specialized Coatings Interacting with Human Pathogens)
The occurrence of opportunistic local infections and improper integration of metallic implants results in severe health conditions. Protective and tunable coatings represent an attractive and challenging selection for improving the metallic devices’ biofunctional performances to restore or replace bone tissue. Composite materials based on hydroxyapatite (HAp), Kanamycin (KAN), and fibroblast growth factor 2 (FGF2) are herein proposed as multifunctional coatings for hard tissue implants. The superior cytocompatibility of the obtained composite coatings was evidenced by performing proliferation and morphological assays on osteoblast cell cultures. The addition of FGF2 proved beneficial concerning the metabolic activity, adhesion, and spreading of cells. The KAN-embedded coatings exhibited significant inhibitory effects against bacterial biofilm development for at least two days, the results being superior in the case of Gram-positive pathogens. HAp-based coatings embedded with KAN and FGF2 protein are proposed as multifunctional materials with superior osseointegration potential and the ability to reduce device-associated infections. View Full-Text
Keywords: metallic implants; antimicrobial coatings; bioactive materials; improved osseointegration; multifunctional device metallic implants; antimicrobial coatings; bioactive materials; improved osseointegration; multifunctional device
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MDPI and ACS Style

Gherasim, O.; Grumezescu, A.M.; Grumezescu, V.; Negut, I.; Dumitrescu, M.F.; Stan, M.S.; Nica, I.C.; Holban, A.M.; Socol, G.; Andronescu, E. Bioactive Coatings Based on Hydroxyapatite, Kanamycin, and Growth Factor for Biofilm Modulation. Antibiotics 2021, 10, 160. https://doi.org/10.3390/antibiotics10020160

AMA Style

Gherasim O, Grumezescu AM, Grumezescu V, Negut I, Dumitrescu MF, Stan MS, Nica IC, Holban AM, Socol G, Andronescu E. Bioactive Coatings Based on Hydroxyapatite, Kanamycin, and Growth Factor for Biofilm Modulation. Antibiotics. 2021; 10(2):160. https://doi.org/10.3390/antibiotics10020160

Chicago/Turabian Style

Gherasim, Oana, Alexandru M. Grumezescu, Valentina Grumezescu, Irina Negut, Marius F. Dumitrescu, Miruna S. Stan, Ionela C. Nica, Alina M. Holban, Gabriel Socol, and Ecaterina Andronescu. 2021. "Bioactive Coatings Based on Hydroxyapatite, Kanamycin, and Growth Factor for Biofilm Modulation" Antibiotics 10, no. 2: 160. https://doi.org/10.3390/antibiotics10020160

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