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Review

Antibiotics- and Heavy Metals-Based Titanium Alloy Surface Modifications for Local Prosthetic Joint Infections

1
Clinical Microbiology Department, Jiménez Díaz Foundation Health Research Institute, Autonomous University of Madrid, Av. Reyes Católicos 2, 28040 Madrid, Spain
2
Networking Research Centre on Infectious Diseases (CIBER-ID), 28029 Madrid, Spain
3
Department of Chemistry in Pharmaceutical Sciences, Research Institute Hospital 12 de Octubre (i+12), School of Pharmacy, Complutense University of Madrid, Pza. Ramón y Cajal s/n, 28040 Madrid, Spain
4
Networking Research Centre on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 28029 Madrid, Spain
*
Authors to whom correspondence should be addressed.
Academic Editors: Helena Felgueiras and Nicholas Dixon
Antibiotics 2021, 10(10), 1270; https://doi.org/10.3390/antibiotics10101270
Received: 21 September 2021 / Revised: 5 October 2021 / Accepted: 13 October 2021 / Published: 19 October 2021
Prosthetic joint infection (PJI) is the second most common cause of arthroplasty failure. Though infrequent, it is one of the most devastating complications since it is associated with great personal cost for the patient and a high economic burden for health systems. Due to the high number of patients that will eventually receive a prosthesis, PJI incidence is increasing exponentially. As these infections are provoked by microorganisms, mainly bacteria, and as such can develop a biofilm, which is in turn resistant to both antibiotics and the immune system, prevention is the ideal approach. However, conventional preventative strategies seem to have reached their limit. Novel prevention strategies fall within two broad categories: (1) antibiotic- and (2) heavy metal-based surface modifications of titanium alloy prostheses. This review examines research on the most relevant titanium alloy surface modifications that use antibiotics to locally prevent primary PJI. View Full-Text
Keywords: prosthetic joint infection; local prevention prosthetic joint infection; local prevention
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MDPI and ACS Style

Esteban, J.; Vallet-Regí, M.; Aguilera-Correa, J.J. Antibiotics- and Heavy Metals-Based Titanium Alloy Surface Modifications for Local Prosthetic Joint Infections. Antibiotics 2021, 10, 1270. https://doi.org/10.3390/antibiotics10101270

AMA Style

Esteban J, Vallet-Regí M, Aguilera-Correa JJ. Antibiotics- and Heavy Metals-Based Titanium Alloy Surface Modifications for Local Prosthetic Joint Infections. Antibiotics. 2021; 10(10):1270. https://doi.org/10.3390/antibiotics10101270

Chicago/Turabian Style

Esteban, Jaime, María Vallet-Regí, and John J. Aguilera-Correa. 2021. "Antibiotics- and Heavy Metals-Based Titanium Alloy Surface Modifications for Local Prosthetic Joint Infections" Antibiotics 10, no. 10: 1270. https://doi.org/10.3390/antibiotics10101270

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