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Antibiotics
Volume 10
Issue 10
10.3390/antibiotics10101269
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Article

Anti-Biofilm Coatings Based on Chitosan and Lysozyme Functionalized Magnetite Nanoparticles

by
Vera Alexandra Spirescu
1,
Adelina-Gabriela Niculescu
1,
Ștefan Slave
1,
Alexandra Cătalina Bîrcă
1,
Gabriela Dorcioman
2,
Valentina Grumezescu
2,
Alina Maria Holban
3,
Ovidiu-Cristian Oprea
4,
Bogdan Ștefan Vasile
1,
Alexandru Mihai Grumezescu
1,5,6,*,
Ionela Cristina Nica
6,7,
Miruna Silvia Stan
6,7 and
Ecaterina Andronescu
1,6
1
Department of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, 011061 Bucharest, Romania
2
Lasers Department, National Institute for Lasers, Plasma and Radiation Physics, 077125 Magurele, Romania
3
Department of Microbiology and Immunology, Faculty of Biology, University of Bucharest, 077206 Bucharest, Romania
4
Department of Inorganic Chemistry, Physical Chemistry and Electrochemistry, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, 011061 Bucharest, Romania
5
Research Institute of the University of Bucharest—ICUB, University of Bucharest, 050657 Bucharest, Romania
6
Academy of Romanian Scientists, Ilfov No. 3, 50044 Bucharest, Romania
7
Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 050095 Bucharest, Romania
*
Author to whom correspondence should be addressed.
Academic Editor: Hao Song
Antibiotics 2021, 10(10), 1269; https://doi.org/10.3390/antibiotics10101269
Received: 15 September 2021 / Revised: 13 October 2021 / Accepted: 15 October 2021 / Published: 19 October 2021
(This article belongs to the Special Issue Antibiotic-Free Antibacterial Strategies Enabled by Nanomaterials)
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Abstract

Biofilms represent a common and increasingly challenging problem in healthcare practices worldwide, producing persistent and difficult to manage infections. Researchers have started developing antibiotic-free treatment alternatives in order to decrease the risk of resistant microbial strain selection and for the efficient management of antibiotic tolerant biofilm infections. The present study reports the fabrication and characterization of magnetite-based nanostructured coatings for producing biofilm-resistant surfaces. Specifically, magnetite nanoparticles (Fe3O4) were functionalized with chitosan (CS) and were blended with lysozyme (LyZ) and were deposited using the matrix-assisted pulsed laser evaporation (MAPLE) technique. A variety of characterization techniques were employed to investigate the physicochemical properties of both nanoparticles and nanocoatings. The biological characterization of the coatings assessed through cell viability and antimicrobial tests showed biocompatibility on osteoblasts as well as antiadhesive and antibiofilm activity against both Gram-negative and Gram-positive bacterial strains and no cytotoxic effect against human-cultured diploid cells. View Full-Text
Keywords: laser processing; lysozyme; magnetite-based coatings; nanostructured bioactive coatings; antimicrobial properties; antibiofilm activity laser processing; lysozyme; magnetite-based coatings; nanostructured bioactive coatings; antimicrobial properties; antibiofilm activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
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MDPI and ACS Style

Spirescu, V.A.; Niculescu, A.-G.; Slave, Ș.; Bîrcă, A.C.; Dorcioman, G.; Grumezescu, V.; Holban, A.M.; Oprea, O.-C.; Vasile, B.Ș.; Grumezescu, A.M.; Nica, I.C.; Stan, M.S.; Andronescu, E. Anti-Biofilm Coatings Based on Chitosan and Lysozyme Functionalized Magnetite Nanoparticles. Antibiotics 2021, 10, 1269. https://doi.org/10.3390/antibiotics10101269

AMA Style

Spirescu VA, Niculescu A-G, Slave Ș, Bîrcă AC, Dorcioman G, Grumezescu V, Holban AM, Oprea O-C, Vasile BȘ, Grumezescu AM, Nica IC, Stan MS, Andronescu E. Anti-Biofilm Coatings Based on Chitosan and Lysozyme Functionalized Magnetite Nanoparticles. Antibiotics. 2021; 10(10):1269. https://doi.org/10.3390/antibiotics10101269

Chicago/Turabian Style

Spirescu, Vera A., Adelina-Gabriela Niculescu, Ștefan Slave, Alexandra C. Bîrcă, Gabriela Dorcioman, Valentina Grumezescu, Alina M. Holban, Ovidiu-Cristian Oprea, Bogdan Ș. Vasile, Alexandru M. Grumezescu, Ionela C. Nica, Miruna S. Stan, and Ecaterina Andronescu. 2021. "Anti-Biofilm Coatings Based on Chitosan and Lysozyme Functionalized Magnetite Nanoparticles" Antibiotics 10, no. 10: 1269. https://doi.org/10.3390/antibiotics10101269

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