Paralemnolins X and Y, New Antimicrobial Sesquiterpenoids from the Soft Coral Paralemnalia thyrsoide
Abstract
:1. Introduction
2. Results and Discussion
3. Materials and Methods
3.1. General Experimental Procedures
3.2. Coral Material, Extraction and Separation
3.3. Spectral data of Paralemnolin X, Y (1,2)
3.4. Antimicrobial Activity Assay
3.4.1. Microorganisms
3.4.2. Minimum Inhibitory Concentration Determination
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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No | 1 | 2 | Paralemnolin F | |||
---|---|---|---|---|---|---|
δH | δC | δH | δC | δH | δC | |
1 | --- | 42.3 | --- | 38.9 | --- | 40.9 |
2 | 2.96 s | 65.3 | 2.89 s | 65.2 | 2.62 s | 71.8 |
3 | --- | 55.4 | --- | 58.3 | --- | 58.7 |
4 | 5.18 d (3.0) | 72.5 | 4.77 d (6.0) | 75.5 | 5.30 br s | 73.6 |
5 | 5.13 dd (11.4, 2.4) | 73.8 | 5.09 dd (10.0, 6.0) | 73.6 | 5.27 m | 71.9 |
6 | 1.82 m, 1.90 m | 31.3 | 1.81 m, 2.10 m | 31.9 | 1.86 m, 1.97 m | 30.2 |
7 | 2.05 m, 2.41 m | 30.0 | 2.40 m, 2.44 m | 32.3 | 2.15m, 2.42 m | 29.8 |
8 | --- | 143.7 | --- | 142.1 | --- | 140.4 |
9 | 5.55 dd (4.3, 2.6) | 127.1 | 5.44 br d (4.5) | 124.2 | 5.58 dd (3.6, 3.8) | 127.8 |
10 | 2.07 m | 25.9 | 1.96 m, 2.00 m | 25.8 | 2.07 m | 25.3 |
11 | 1.42 m, 1.46 m | 25.3 | 1.36 m, 1.44 m | 26.3 | 1.50 m | 25.9 |
12 | 1.80 m | 39.6 | 1.77 m | 32.3 | 1.73 m | 42.8 |
13 | 0.80 s | 14.5 | 1.20 s | 21.9 | 0.98 s | 17.0 |
14 | 1.73 s | 19.5 | 1.48 s | 13.9 | 1.48 s | 20.7 |
15 | 0.98 d (6.9) | 16.9 | 0.94 d (6.9) | 17.7 | 0.97 d (6.9) | 16.2 |
CH3-AC | 2.00 s, 2.08 s | 21.0 | 2.11 s, 2.02 s | 20.7, 20.9 | 2.07s, 2.09 s | 20.9, 21.1 |
C=O-Ac | --- | 169.9 | --- | 169.7, 169.9 | 170.0, 169.9 |
Compound No. | Staphylococcus aureus | Escherichia coli | Candida albicans | Aspergillus niger |
---|---|---|---|---|
1 | 1.488 | - | - | - |
2 | 1.488 | - | - | - |
3 | 0.899 | - | - | 1.798 |
4 | 1.562 | - | - | 1.562 |
5 | 0.449 | 1.798 | 1.798 | 2.248 |
6 | 1.893 | - | - | - |
7 | - | - | - | - |
8 | 0.221 | - | - | 1.773 |
9 | 1.785 | - | 1.785 | 0.446 |
10 | 2.110 | - | - | 1.059 |
11 | 1.785 | - | - | 0.446 |
12 | 0.992 | - | - | 0.992 |
Treflucan | - | - | 0.327 | 0.163 |
Thiophenicol | 0.140 | 0.281 | - | - |
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Elshamy, A.I.; Mohamed, T.A.; Elkady, E.M.; Saleh, I.A.; El-Beih, A.A.; Alhammady, M.A.; Ohta, S.; Umeyama, A.; Paré, P.W.; Hegazy, M.-E.F. Paralemnolins X and Y, New Antimicrobial Sesquiterpenoids from the Soft Coral Paralemnalia thyrsoide. Antibiotics 2021, 10, 1158. https://doi.org/10.3390/antibiotics10101158
Elshamy AI, Mohamed TA, Elkady EM, Saleh IA, El-Beih AA, Alhammady MA, Ohta S, Umeyama A, Paré PW, Hegazy M-EF. Paralemnolins X and Y, New Antimicrobial Sesquiterpenoids from the Soft Coral Paralemnalia thyrsoide. Antibiotics. 2021; 10(10):1158. https://doi.org/10.3390/antibiotics10101158
Chicago/Turabian StyleElshamy, Abdelsamed I., Tarik A. Mohamed, Eman M. Elkady, Ibrahim A. Saleh, Ahmed A. El-Beih, Montaser A. Alhammady, Shinji Ohta, Akemi Umeyama, Paul W. Paré, and Mohamed-Elamir F. Hegazy. 2021. "Paralemnolins X and Y, New Antimicrobial Sesquiterpenoids from the Soft Coral Paralemnalia thyrsoide" Antibiotics 10, no. 10: 1158. https://doi.org/10.3390/antibiotics10101158