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Biosensors 2018, 8(3), 78; https://doi.org/10.3390/bios8030078

Design and Fabrication of a BiCMOS Dielectric Sensor for Viscosity Measurements: A Possible Solution for Early Detection of COPD

1
IHP, Im Technologiepark 25, 15236 Frankfurt/Oder, Germany
2
Institute of High-Frequency and Semiconductor System Technologies, Technical University of Berlin, 10623 Berlin, Germany
3
Brandenburg Medical School Theodor Fontane, 16816 Berlin, Germany
*
Author to whom correspondence should be addressed.
Received: 22 June 2018 / Revised: 8 August 2018 / Accepted: 17 August 2018 / Published: 21 August 2018
(This article belongs to the Special Issue Smart Biomedical Sensors)
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Abstract

The viscosity variation of sputum is a common symptom of the progression of Chronic Obstructive Pulmonary Disease (COPD). Since the hydration of the sputum defines its viscosity level, dielectric sensors could be used for the characterization of sputum samples collected from patients for early diagnosis of COPD. In this work, a CMOS-based dielectric sensor for the real-time monitoring of sputum viscosity was designed and fabricated. A proper packaging for the ESD-protection and short-circuit prevention of the sensor was developed. The performance evaluation results show that the radio frequency sensor is capable of measuring dielectric constant of biofluids with an accuracy of 4.17%. Integration of this sensor into a portable system will result in a hand-held device capable of measuring viscosity of sputum samples of COPD-patients for diagnostic purposes. View Full-Text
Keywords: Sputum–Mucin; dielectric measurements; CMOS viscosity sensor; radio frequency sensor; Viscometer; biosensors; precision diagnostics Sputum–Mucin; dielectric measurements; CMOS viscosity sensor; radio frequency sensor; Viscometer; biosensors; precision diagnostics
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Soltani Zarrin, P.; Jamal, F.I.; Guha, S.; Wessel, J.; Kissinger, D.; Wenger, C. Design and Fabrication of a BiCMOS Dielectric Sensor for Viscosity Measurements: A Possible Solution for Early Detection of COPD. Biosensors 2018, 8, 78.

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