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Biosensors 2018, 8(2), 46; https://doi.org/10.3390/bios8020046

In Vitro and In Vivo SERS Biosensing for Disease Diagnosis

Department of Chemistry, The University of Tennessee, 1420 Circle Drive, Knoxville, TN 37996, USA
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Received: 2 April 2018 / Revised: 7 May 2018 / Accepted: 10 May 2018 / Published: 11 May 2018
(This article belongs to the Special Issue SERS-Based Sensors: Design and Biomedical Applications)
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Abstract

For many disease states, positive outcomes are directly linked to early diagnosis, where therapeutic intervention would be most effective. Recently, trends in disease diagnosis have focused on the development of label-free sensing techniques that are sensitive to low analyte concentrations found in the physiological environment. Surface-enhanced Raman spectroscopy (SERS) is a powerful vibrational spectroscopy that allows for label-free, highly sensitive, and selective detection of analytes through the amplification of localized electric fields on the surface of a plasmonic material when excited with monochromatic light. This results in enhancement of the Raman scattering signal, which allows for the detection of low concentration analytes, giving rise to the use of SERS as a diagnostic tool for disease. Here, we present a review of recent developments in the field of in vivo and in vitro SERS biosensing for a range of disease states including neurological disease, diabetes, cardiovascular disease, cancer, and viral disease. View Full-Text
Keywords: SERS; biosensing; diagnostics; neurological disease; diabetes; cardiovascular disease; cancer; viral disease SERS; biosensing; diagnostics; neurological disease; diabetes; cardiovascular disease; cancer; viral disease
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Moore, T.J.; Moody, A.S.; Payne, T.D.; Sarabia, G.M.; Daniel, A.R.; Sharma, B. In Vitro and In Vivo SERS Biosensing for Disease Diagnosis. Biosensors 2018, 8, 46.

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