Next Article in Journal
AC and Phase Sensing of Nanowires for Biosensing
Next Article in Special Issue
Electronic Biosensing with Functionalized rGO FETs
Previous Article in Journal
Infrared Spectroscopy of Bilberry Extract Water-in-Oil Emulsions: Sensing the Water-Oil Interface
Previous Article in Special Issue
Measurement of Rapid Amiloride-Dependent pH Changes at the Cell Surface Using a Proton-Sensitive Field-Effect Transistor
Open AccessReview

Droplet-based Biosensing for Lab-on-a-Chip, Open Microfluidics Platforms

Purdue University, West Lafayette 47906, IN, USA
University of Illinois at Urbana-Champaign, Urbana 61801, IL, USA
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Mark A. Reed and Mathias Wipf
Biosensors 2016, 6(2), 14;
Received: 11 February 2016 / Revised: 31 March 2016 / Accepted: 9 April 2016 / Published: 14 April 2016
(This article belongs to the Special Issue Field-Effect Transistor Biosensors)
Low cost, portable sensors can transform health care by bringing easily available diagnostic devices to low and middle income population, particularly in developing countries. Sample preparation, analyte handling and labeling are primary cost concerns for traditional lab-based diagnostic systems. Lab-on-a-chip (LoC) platforms based on droplet-based microfluidics promise to integrate and automate these complex and expensive laboratory procedures onto a single chip; the cost will be further reduced if label-free biosensors could be integrated onto the LoC platforms. Here, we review some recent developments of label-free, droplet-based biosensors, compatible with “open” digital microfluidic systems. These low-cost droplet-based biosensors overcome some of the fundamental limitations of the classical sensors, enabling timely diagnosis. We identify the key challenges that must be addressed to make these sensors commercially viable and summarize a number of promising research directions. View Full-Text
Keywords: droplet; biosensors; lab-on-a-chip; early detection; point-of-care; high sensitivity droplet; biosensors; lab-on-a-chip; early detection; point-of-care; high sensitivity
Show Figures

Graphical abstract

MDPI and ACS Style

Dak, P.; Ebrahimi, A.; Swaminathan, V.; Duarte-Guevara, C.; Bashir, R.; Alam, M.A. Droplet-based Biosensing for Lab-on-a-Chip, Open Microfluidics Platforms. Biosensors 2016, 6, 14.

AMA Style

Dak P, Ebrahimi A, Swaminathan V, Duarte-Guevara C, Bashir R, Alam MA. Droplet-based Biosensing for Lab-on-a-Chip, Open Microfluidics Platforms. Biosensors. 2016; 6(2):14.

Chicago/Turabian Style

Dak, Piyush; Ebrahimi, Aida; Swaminathan, Vikhram; Duarte-Guevara, Carlos; Bashir, Rashid; Alam, Muhammad A. 2016. "Droplet-based Biosensing for Lab-on-a-Chip, Open Microfluidics Platforms" Biosensors 6, no. 2: 14.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop