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Biosensors 2016, 6(2), 14;

Droplet-based Biosensing for Lab-on-a-Chip, Open Microfluidics Platforms

Purdue University, West Lafayette 47906, IN, USA
University of Illinois at Urbana-Champaign, Urbana 61801, IL, USA
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editors: Mark A. Reed and Mathias Wipf
Received: 11 February 2016 / Revised: 31 March 2016 / Accepted: 9 April 2016 / Published: 14 April 2016
(This article belongs to the Special Issue Field-Effect Transistor Biosensors)
Full-Text   |   PDF [2704 KB, uploaded 14 April 2016]   |  


Low cost, portable sensors can transform health care by bringing easily available diagnostic devices to low and middle income population, particularly in developing countries. Sample preparation, analyte handling and labeling are primary cost concerns for traditional lab-based diagnostic systems. Lab-on-a-chip (LoC) platforms based on droplet-based microfluidics promise to integrate and automate these complex and expensive laboratory procedures onto a single chip; the cost will be further reduced if label-free biosensors could be integrated onto the LoC platforms. Here, we review some recent developments of label-free, droplet-based biosensors, compatible with “open” digital microfluidic systems. These low-cost droplet-based biosensors overcome some of the fundamental limitations of the classical sensors, enabling timely diagnosis. We identify the key challenges that must be addressed to make these sensors commercially viable and summarize a number of promising research directions. View Full-Text
Keywords: droplet; biosensors; lab-on-a-chip; early detection; point-of-care; high sensitivity droplet; biosensors; lab-on-a-chip; early detection; point-of-care; high sensitivity

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Dak, P.; Ebrahimi, A.; Swaminathan, V.; Duarte-Guevara, C.; Bashir, R.; Alam, M.A. Droplet-based Biosensing for Lab-on-a-Chip, Open Microfluidics Platforms. Biosensors 2016, 6, 14.

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