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Biosensors 2016, 6(2), 15;

AC and Phase Sensing of Nanowires for Biosensing

Department of Electrical, Electronic and Information Engineering, University of Bologna, Cesena Campus, Cesena 47521, Italy
School of Electronics and Computer Sciences, and the Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK
Author to whom correspondence should be addressed.
Academic Editor: Ebrahim Ghafar-Zadeh
Received: 28 January 2016 / Revised: 6 April 2016 / Accepted: 9 April 2016 / Published: 19 April 2016
(This article belongs to the Special Issue Micro- and Nano-Bio-Interfaces)
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Silicon nanowires are label-free sensors that allow real-time measurements. They are economical and pave the road for point-of-care applications but require complex readout and skilled personnel. We propose a new model and technique for sensing nanowire sensors using alternating currents (AC) to capture both magnitude and phase information from the sensor. This approach combines the advantages of complex impedance spectroscopy with the noise reduction performances of lock-in techniques. Experimental results show how modifications of the sensors with different surface chemistries lead to the same direct-current (DC) response but can be discerned using the AC approach. View Full-Text
Keywords: nanowires; nanosensors; phase detection; impedance spectroscopy; AC sensing nanowires; nanosensors; phase detection; impedance spectroscopy; AC sensing

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Crescentini, M.; Rossi, M.; Ashburn, P.; Lombardini, M.; Sangiorgi, E.; Morgan, H.; Tartagni, M. AC and Phase Sensing of Nanowires for Biosensing. Biosensors 2016, 6, 15.

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