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Article

High Fundamental Frequency (HFF) Monolithic Quartz Crystal Microbalance with Dissipation Array for the Simultaneous Detection of Pesticides and Antibiotics in Complex Food

1
Centro de Investigación e Innovación en Bioingeniería (Ci2B), Universitat Politècnica de València, Camino de Vera s/n, 46022 Valencia, Spain
2
Advanced Wave Sensors S.L., Calle Algepser 24, 46988 Paterna, Valencia, Spain
3
Instituto de Ingeniería de Alimentos para el Desarrollo (IIAD), Universitat Politècnica de València, Camino de Vera s/n, 46022 Valencia, Spain
*
Author to whom correspondence should be addressed.
Biosensors 2022, 12(6), 433; https://doi.org/10.3390/bios12060433
Received: 24 May 2022 / Revised: 15 June 2022 / Accepted: 17 June 2022 / Published: 20 June 2022
As in the case of the food industry in general, there is a global concern about safety and quality in complex food matrices, such as honey, which is driving the demand for fast, sensitive and affordable analytical techniques across the honey-packaging industry. Although excellent techniques such as liquid chromatography-tandem mass spectrometry (LC-MS/MS) are available, these are located in centralized laboratories and are still lacking in speed, simplicity and cost-effectiveness. Here, a new approach is presented where a competitive immunoassay is combined with a novel High Fundamental Frequency Quartz Crystal Microbalance with Dissipation (HFF-QCMD) array biosensor for the simultaneous detection of antibiotics and pesticides in honey. Concretely, thiabendazole and sulfathiazole residues were monitored in spiked honey samples. Results revealed that HFF-QCMD arrays provide a complementary and reliable tool to LC-MS/MS for the analysis of contaminants in these kinds of complex matrices, while avoiding elaborate sample pre-treatment. The good sensitivity achieved (I50 values in the 70–720 µg/kg range) and the short analysis time (60 min for 24 individual assays), together with the ability for multiple analyte detection (24 sensor array) and its cost-effectiveness, pave the way for the implementation of a fast on-line, in situ routine control of potentially hazardous chemical residues in honey. View Full-Text
Keywords: immunosensor; HFF-QCMD array; honey; antibiotic; pesticide immunosensor; HFF-QCMD array; honey; antibiotic; pesticide
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MDPI and ACS Style

Calero, M.; Fernández, R.; García, M.; Juan-Borrás, M.; Escriche, I.; Arnau, A.; Montoya, Á.; Jiménez, Y. High Fundamental Frequency (HFF) Monolithic Quartz Crystal Microbalance with Dissipation Array for the Simultaneous Detection of Pesticides and Antibiotics in Complex Food. Biosensors 2022, 12, 433. https://doi.org/10.3390/bios12060433

AMA Style

Calero M, Fernández R, García M, Juan-Borrás M, Escriche I, Arnau A, Montoya Á, Jiménez Y. High Fundamental Frequency (HFF) Monolithic Quartz Crystal Microbalance with Dissipation Array for the Simultaneous Detection of Pesticides and Antibiotics in Complex Food. Biosensors. 2022; 12(6):433. https://doi.org/10.3390/bios12060433

Chicago/Turabian Style

Calero, María, Román Fernández, María García, Marisol Juan-Borrás, Isabel Escriche, Antonio Arnau, Ángel Montoya, and Yolanda Jiménez. 2022. "High Fundamental Frequency (HFF) Monolithic Quartz Crystal Microbalance with Dissipation Array for the Simultaneous Detection of Pesticides and Antibiotics in Complex Food" Biosensors 12, no. 6: 433. https://doi.org/10.3390/bios12060433

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