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Gold Nanorods for LSPR Biosensing: Synthesis, Coating by Silica, and Bioanalytical Applications

1
Laboratoire de Réactivité de Surface (LRS), Sorbonne Université, CNRS, UMR 7197, 4 Place Jussieu, F-75005 Paris, France
2
Institut Parisien de Chimie Moléculaire (IPCM), Sorbonne Université, CNRS, 4 Place Jussieu, F-75005 Paris, France
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Biosensors 2020, 10(10), 146; https://doi.org/10.3390/bios10100146
Received: 2 September 2020 / Revised: 12 October 2020 / Accepted: 13 October 2020 / Published: 17 October 2020
(This article belongs to the Special Issue Surface Plasmon Resonance for Biosensing)
Nanoparticles made of coinage metals are well known to display unique optical properties stemming from the localized surface plasmon resonance (LSPR) phenomenon, allowing their use as transducers in various biosensing configurations. While most of the reports initially dealt with spherical gold nanoparticles owing to their ease of synthesis, the interest in gold nanorods (AuNR) as plasmonic biosensors is rising steadily. These anisotropic nanoparticles exhibit, on top of the LSPR band in the blue range common with spherical nanoparticles, a longitudinal LSPR band, in all respects superior, and in particular in terms of sensitivity to the surrounding media and LSPR-biosensing. However, AuNRs synthesis and their further functionalization are less straightforward and require thorough processing. In this paper, we intend to give an up-to-date overview of gold nanorods in LSPR biosensing, starting from a critical review of the recent findings on AuNR synthesis and the main challenges related to it. We further highlight the various strategies set up to coat AuNR with a silica shell of controlled thickness and porosity compatible with LSPR-biosensing. Then, we provide a survey of the methods employed to attach various bioreceptors to AuNR. Finally, the most representative examples of AuNR-based LSPR biosensors are reviewed with a focus put on their analytical performances. View Full-Text
Keywords: gold nanorods; silica coating; localized surface plasmon resonance (LSPR); surface functionalization gold nanorods; silica coating; localized surface plasmon resonance (LSPR); surface functionalization
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MDPI and ACS Style

Pellas, V.; Hu, D.; Mazouzi, Y.; Mimoun, Y.; Blanchard, J.; Guibert, C.; Salmain, M.; Boujday, S. Gold Nanorods for LSPR Biosensing: Synthesis, Coating by Silica, and Bioanalytical Applications. Biosensors 2020, 10, 146.

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