Next Article in Journal
Fabrication of Crystalline Microresonators of High Quality Factors with a Controllable Wedge Angle on Lithium Niobate on Insulator
Next Article in Special Issue
Spatially Resolved Optoelectronic Properties of Al-Doped Zinc Oxide Thin Films Deposited by Radio-Frequency Magnetron Plasma Sputtering Without Substrate Heating
Previous Article in Journal
Improved Laser Damage Threshold of In2Se3 Saturable Absorber by PVD for High-Power Mode-Locked Er-Doped Fiber Laser
Previous Article in Special Issue
Design of Nanoscaled Surface Morphology of TiO2–Ag2O Composite Nanorods through Sputtering Decoration Process and Their Low-Concentration NO2 Gas-Sensing Behaviors
Open AccessArticle

Antibacterial Nanostructured Ti Coatings by Magnetron Sputtering: From Laboratory Scales to Industrial Reactors

1
Instituto de Ciencia de Materiales de Sevilla (CSIC-US), Américo Vespucio 49, 41092 Seville, Spain
2
Departamento de Física Aplicada I, Escuela Politécnica Superior, Universidad de Sevilla, c/Virgen de África 7, 41011 Seville, Spain
3
Nano4Energy SLNE, C/Jose Gutierrez Abascal 2, 28006 Madrid, Spain
4
Instituto de Micro y Nanotecnología, IMN-CNM, CSIC (CEI UAM + CSIC), Isaac Newton 8, 28760 Tres Cantos, Madrid, Spain
5
Dpto de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Hospital 12 de Octubre i+12, Plaza Ramón y Cajal s/n, 28040 Madrid, Spain
6
CIBER de Bioingeniería Biomateriales y Nanomedicina (CIBER-BBN), 28029 Madrid, Spain
*
Authors to whom correspondence should be addressed.
Nanomaterials 2019, 9(9), 1217; https://doi.org/10.3390/nano9091217
Received: 31 July 2019 / Revised: 21 August 2019 / Accepted: 27 August 2019 / Published: 28 August 2019
Based on an already tested laboratory procedure, a new magnetron sputtering methodology to simultaneously coat two-sides of large area implants (up to ~15 cm2) with Ti nanocolumns in industrial reactors has been developed. By analyzing the required growth conditions in a laboratory setup, a new geometry and methodology have been proposed and tested in a semi-industrial scale reactor. A bone plate (DePuy Synthes) and a pseudo-rectangular bone plate extracted from a patient were coated following the new methodology, obtaining that their osteoblast proliferation efficiency and antibacterial functionality were equivalent to the coatings grown in the laboratory reactor on small areas. In particular, two kinds of experiments were performed: Analysis of bacterial adhesion and biofilm formation, and osteoblasts–bacteria competitive in vitro growth scenarios. In all these cases, the coatings show an opposite behavior toward osteoblast and bacterial proliferation, demonstrating that the proposed methodology represents a valid approach for industrial production and practical application of nanostructured titanium coatings. View Full-Text
Keywords: magnetron sputtering; oblique angle deposition; nanostructured titanium thin films; antibacterial coatings; osteoblast proliferation; industrial scale magnetron sputtering; oblique angle deposition; nanostructured titanium thin films; antibacterial coatings; osteoblast proliferation; industrial scale
Show Figures

Figure 1

MDPI and ACS Style

Alvarez, R.; Muñoz-Piña, S.; González, M.U.; Izquierdo-Barba, I.; Fernández-Martínez, I.; Rico, V.; Arcos, D.; García-Valenzuela, A.; Palmero, A.; Vallet-Regi, M.; González-Elipe, A.R.; García-Martín, J.M. Antibacterial Nanostructured Ti Coatings by Magnetron Sputtering: From Laboratory Scales to Industrial Reactors. Nanomaterials 2019, 9, 1217.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop