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Article

Nanoencapsulation Enhances Anticoagulant Activity of Adenosine and Dipeptide IleTrp

1
Institute of Research and Development, Duy Tan University, Da Nang City 550000, Vietnam
2
Institute of Applied Materials Science, Vietnam Academy of Science and Technology, Ho Chi Minh City 700000, Vietnam
3
Graduate University of Science and Technology, Vietnam Academy of Science and Technology Ho Chi Minh City 700000, Vietnam
4
Tra Vinh University, Tra Vinh City 940000, Vietnam
5
Faculty of Pharmacy, Nguyen Tat Thanh University, Ho Chi Minh City 700000, Vietnam
6
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Science, 119991 Moscow, Russia
*
Author to whom correspondence should be addressed.
Nanomaterials 2019, 9(9), 1191; https://doi.org/10.3390/nano9091191
Received: 27 July 2019 / Revised: 10 August 2019 / Accepted: 21 August 2019 / Published: 23 August 2019
It is well-known that drugs administered into an organism intravenously or through the gastrointestinal tract are degraded by enzymes of the body, reducing their therapeutic effect. One of the ways to decrease this undesirable process is through the inclusion of drugs in nanomaterials. Earlier strong anticoagulant activity was demonstrated for dipeptide IleTrp (IW) and adenosine (Ado). In this work, the effect of inclusion in nanomaterials on the biological activity of IW and Ado was studied. For this purpose, Ado and IW were incorporated into thermosensitive nanogel composed of pluronic P123-grafted heparin. The prepared nanocarrier was characterized by transmission electron microscopy, dynamic light scattering, and ζ-potential. Biological activity was determined by measuring the bleeding time from mouse tail in vivo and the time of clot formation in vitro. It was found that encapsulation of Ado and IW into nanomaterial significantly increased their effects, resulting in an increase in the bleeding time from mouse tail and clot formation time. Thus, inclusion of low molecular weight anticoagulants Ado and IW into nanomaterials may be considered a way to increase their biological activity. View Full-Text
Keywords: anticoagulant; adenosine; heparin; pluronic P123; nanogel anticoagulant; adenosine; heparin; pluronic P123; nanogel
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MDPI and ACS Style

Nguyen, T.D.; Nguyen, T.N.; Nguyen, T.T.T.; Ivanov, I.A.; Nguyen, K.C.; Tran, Q.N.; Hoang, A.N.; Utkin, Y.N. Nanoencapsulation Enhances Anticoagulant Activity of Adenosine and Dipeptide IleTrp. Nanomaterials 2019, 9, 1191. https://doi.org/10.3390/nano9091191

AMA Style

Nguyen TD, Nguyen TN, Nguyen TTT, Ivanov IA, Nguyen KC, Tran QN, Hoang AN, Utkin YN. Nanoencapsulation Enhances Anticoagulant Activity of Adenosine and Dipeptide IleTrp. Nanomaterials. 2019; 9(9):1191. https://doi.org/10.3390/nano9091191

Chicago/Turabian Style

Nguyen, Trung D., The N. Nguyen, Trang T.T. Nguyen, Igor A. Ivanov, Khoa C. Nguyen, Quyen N. Tran, Anh N. Hoang, and Yuri N. Utkin 2019. "Nanoencapsulation Enhances Anticoagulant Activity of Adenosine and Dipeptide IleTrp" Nanomaterials 9, no. 9: 1191. https://doi.org/10.3390/nano9091191

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