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Open AccessArticle

Carvacrol Loaded Solid Lipid Nanoparticles of Propylene Glycol Monopalmitate and Glyceryl Monostearate: Preparation, Characterization, and Synergistic Antimicrobial Activity

1
Key Laboratory for Deep Processing of Major Grain and Oil, Ministry of Education, College of Food Science & Engineering, Wuhan Polytechnic University, Wuhan 430023, China
2
Hubei Key Laboratory for Processing and Transformation of Agricultural Products, Wuhan Polytechnic University, Wuhan 430023, China
3
Beijing Key Lab of Flavor Chemistry, Beijing Technology and Business University, Beijing 100048, China
4
Department of Food Science, The University of Tennessee, Knoxville, TN 37996, USA
*
Author to whom correspondence should be addressed.
Nanomaterials 2019, 9(8), 1162; https://doi.org/10.3390/nano9081162
Received: 23 July 2019 / Revised: 10 August 2019 / Accepted: 12 August 2019 / Published: 14 August 2019
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Abstract

To develop solid lipid nanoparticles (SLNs) with stable lipid matrix structures for the delivery of bioactive compounds, a new class of SLNs was studied using propylene glycol monopalmitate (PGMP) and glyceryl monostearate (GMS) mixtures and carvacrol as a model lipophilic antimicrobial. Stable SLNs were fabricated at PGMP:GMS mass ratios of 2:1 and 1:1, and the carvacrol loading was up to 30% of lipids with >98% encapsulation efficiency and absence of visual instability. Fluorescence spectra and release profiles indicated the carvacrol was successfully encapsulated and homogeneously distributed within the SLNs. SLNs fabricated with equal masses of PGMP and GMS had better stability of carvacrol during storage and higher sphericity than those with a ratio of 2:1 and were much more effective than free carvacrol against Escherichia coli O157:H7 and Staphylococcus aureus. These findings demonstrated the potential applications of the studied SLNs in delivering lipophilic bioactive compounds in food and other products. View Full-Text
Keywords: solid lipid nanoparticles; carvacrol; propylene glycol monopalmitate; synergistic antimicrobial activity solid lipid nanoparticles; carvacrol; propylene glycol monopalmitate; synergistic antimicrobial activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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He, J.; Huang, S.; Sun, X.; Han, L.; Chang, C.; Zhang, W.; Zhong, Q. Carvacrol Loaded Solid Lipid Nanoparticles of Propylene Glycol Monopalmitate and Glyceryl Monostearate: Preparation, Characterization, and Synergistic Antimicrobial Activity. Nanomaterials 2019, 9, 1162.

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