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Open AccessArticle

Fabrication of Stable Nanofiber Matrices for Tissue Engineering via Electrospinning of Bare Laser-Synthesized Au Nanoparticles in Solutions of High Molecular Weight Chitosan

1
Faculty of Technology and Bionics, Rhine-Waal University of Applied Science, Marie-Curie-Straβe 1, 47533 Kleve, Germany
2
Aix Marseille University, CNRS, LP3 (UMR 7341), 13288 Marseille, France
3
MEPhI, Institute of Engineering Physics for Biomedicine (PhysBio), 115409 Moscow, Russia
*
Authors to whom correspondence should be addressed.
Nanomaterials 2019, 9(8), 1058; https://doi.org/10.3390/nano9081058
Received: 14 June 2019 / Revised: 12 July 2019 / Accepted: 19 July 2019 / Published: 24 July 2019
(This article belongs to the Special Issue Soft, Biological and Composite Nanomaterials)
We report a methodology for the fabrication of neutralized chitosan-based nanofiber matrices decorated with bare Au nanoparticles, which demonstrate stable characteristics even after prolonged contact with a biological environment. The methodology consists of electrospinning of a mixture of bare (ligand-free) laser-synthesized Au nanoparticles (AuNPs) and solutions of chitosan/polyethylene oxide (ratio 1/3) containing chitosan of a relatively high molecular weight (200 kDa) and concentration of 3% (w/v). Our studies reveal a continuous morphology of hybrid nanofibers with the mean fiber diameter of 189 nm ± 86 nm, which demonstrate a high thermal stability. Finally, we describe a protocol for the neutralization of nanofibers, which enabled us to achieve their structural stability in phosphate-buffered saline (PBS) for more than six months, as confirmed by microscopy and FTIR measurements. The formed hybrid nanofibers exhibit unique physicochemical properties essential for the development of future tissue engineering platforms. View Full-Text
Keywords: electrospinning; laser ablation; nanofibers; chitosan; poly(ethylene oxide) (PEO); Au nanoparticles; neutralization electrospinning; laser ablation; nanofibers; chitosan; poly(ethylene oxide) (PEO); Au nanoparticles; neutralization
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Nirwan, V.P.; Al-Kattan, A.; Fahmi, A.; Kabashin, A.V. Fabrication of Stable Nanofiber Matrices for Tissue Engineering via Electrospinning of Bare Laser-Synthesized Au Nanoparticles in Solutions of High Molecular Weight Chitosan. Nanomaterials 2019, 9, 1058.

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