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The Impact of Surface Functionalization on the Biophysical Properties of Silver Nanoparticles

1
Laboratory of Biophysics, Intercollegiate Faculty of Biotechnology UG-MUG, University of Gdansk, 80-307 Gdansk, Poland
2
Laboratory of Biologically Active Compounds, IFB UG-MUG, University of Gdansk, 80-307 Gdansk, Poland
3
Laboratory of Virus Molecular Biology, IFB UG-MUG, University of Gdansk, 80-307 Gdansk, Poland
4
Faculty of Chemistry, University of Gdansk, 80-308 Gdansk, Poland
5
Department of Biophysics and Medical Informatics, Taras Shevchenko National University of Kyiv, 01601 Kyiv, Ukraine
6
Institute of Physics of NAS of Ukraine, 03028 Kyiv, Ukraine
7
Faculty of Chemistry, Division of Analytic Chemistry and Chemical Metallurgy, Wroclaw University of Technology, 50-373 Wroclaw, Poland
*
Authors to whom correspondence should be addressed.
Nanomaterials 2019, 9(7), 973; https://doi.org/10.3390/nano9070973
Received: 7 June 2019 / Revised: 28 June 2019 / Accepted: 28 June 2019 / Published: 3 July 2019
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Abstract

Among metal-based nanoparticles, silver nanoparticles (AgNPs) are particularly appealing because of their stability, functionality, and documented antimicrobial properties. AgNPs also offer the possibility of different surface modifications. In this work, we functionalized AgNPs with thiobarbituric acid or 11-mercaptoundecanoic acid residues to improve the nanoparticles’ biological activities. Subsequently, we assessed the physicochemical properties of newly synthesized AgNPs using a wide range of biophysical methodologies, including UV/vis and fluorescence spectroscopy, atomic force and scanning electron microscopy, and dynamic light scattering and isothermal titration calorimetry. Next, we examined the effect of nanoparticles functionalization on AgNPs mutagenicity and toxicity. Our study revealed that AgNPs’ surface modification affects nanoparticles aggregation, and also impacts nanoparticles’ interaction with model acridine mutagen ICR-191. AgNPs coated with MUA showed the most interesting interactions with tested ICR-191, slightly modulating its toxicity properties by decreasing the viability in treated cells. View Full-Text
Keywords: silver nanoparticles; synthesis; surface functionalization; mutagenicity; Ames test; toxicity silver nanoparticles; synthesis; surface functionalization; mutagenicity; Ames test; toxicity
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Borowik, A.; Butowska, K.; Konkel, K.; Banasiuk, R.; Derewonko, N.; Wyrzykowski, D.; Davydenko, M.; Cherepanov, V.; Styopkin, V.; Prylutskyy, Y.; Pohl, P.; Krolicka, A.; Piosik, J. The Impact of Surface Functionalization on the Biophysical Properties of Silver Nanoparticles. Nanomaterials 2019, 9, 973.

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