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Preparation and Performance of Antibacterial Polyvinyl Alcohol/Polyethylene Glycol/Chitosan Hydrogels Containing Silver Chloride Nanoparticles via One-step Method

1,2, 2,* and 1,2,*
1
College of Materials Science and Metallurgy Engineering, Guizhou University, Guiyang 550025, China
2
National Engineering Research Center for Compounding and Modification of Polymeric Materials, National and Local Joint Engineering Research Center for Functional Polymer Membrane Materials and Membrane Processes, Guiyang 550014, China
*
Authors to whom correspondence should be addressed.
Nanomaterials 2019, 9(7), 972; https://doi.org/10.3390/nano9070972
Received: 23 April 2019 / Revised: 24 June 2019 / Accepted: 28 June 2019 / Published: 3 July 2019
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Abstract

Silver nano-particles (AgNPs)-filled antibacterial materials have been widely employed in the fields of biology and biomedicine. However, AgNPs have shown obvious cytotoxicity. Hence it is more reasonable to use silver chloride nanoparticles (AgCl NPs) to prepare antibacterial materials due to the slow release of silver ions created by AgCl NPs formed in the chitosan. In this experiment, a useful antibacterial hydrogel for skin repairation was prepared by exploring the relationship between AgCl NPs and cytotoxicity. It is worth noting that the crosslinked network structure was successfully obtained in an antibacterial AgCl/PVA (Polyvinyl alcohol)/PEG (Polyethylene glycol)/CS (Chitosan) hydrogel materials by the hydrothermal method. In detail, the dynamic particle size distribution of AgCl NPs was relatively uniform, which is analyzed by a dynamic light scattering (DLS). The internal structure of the lyophilized hydrogel showed obvious porous structure, indicating that the hydrogel had high water content. The result of X-ray photoelectron spectroscopy (XPS) confirmed the existence of a silver element. The release concentration of silver ions was analyzed by inductively coupled plasma (ICP) to study the effect of silver ions release concentration on the antibacterial activity and cytotoxicity of hydrogel. The results show that the lower concentration of silver ions can make the hydrogel have good antibacterial activity and low cytotoxicity. The bacteriostatic rate of the antibacterial hydrogel was over 90%. Simultaneously, the mechanical properties test shows that the hydrogel has good mechanical properties, which can be widely used as an antibacterial material. View Full-Text
Keywords: silver chloride nanoparticles; hydrogels; mechanical properties; antibacterial activity silver chloride nanoparticles; hydrogels; mechanical properties; antibacterial activity
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Li, G.; Zhang, D.; Qin, S. Preparation and Performance of Antibacterial Polyvinyl Alcohol/Polyethylene Glycol/Chitosan Hydrogels Containing Silver Chloride Nanoparticles via One-step Method. Nanomaterials 2019, 9, 972.

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