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A Photocleavable Amphiphilic Prodrug Self-Assembled Nanoparticles with Effective Anticancer Activity In Vitro

College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, China
Department of Pharmaceutics, School of Pharmacy, Qingdao University, Qingdao 266021, China
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Nanomaterials 2019, 9(6), 860;
Received: 10 April 2019 / Revised: 18 May 2019 / Accepted: 22 May 2019 / Published: 5 June 2019
(This article belongs to the Special Issue Polymeric Micelles and Their Application in Nanomedicine)
PDF [3653 KB, uploaded 12 June 2019]


Accelerating degradation of prodrug is an effective strategy for improving the pharmacological action. A photocleavable amphiphilic prodrug of methotrexate-coumarin derivative-PEG conjugates (MTX-AMC-PEG) with photo-triggered breakage to release clinical drug under laser irradiation was fabricated and self-assembled into nanoparticles for chemotherapy. The nanoparticles exhibited good intracellular uptake and excellent photolysis release of MTX, which resulted in efficient anticancer activity in vitro with laser irradiation. This research provides a way to fabricate photocleavable prodrug nanoparticles with stimuli-triggered drug release behavior. View Full-Text
Keywords: prodrug; photocleavable; stimuli-responsive release; methotrexate; chemotherapy prodrug; photocleavable; stimuli-responsive release; methotrexate; chemotherapy

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Chen, J.; Li, G.; Liu, Q.; Liang, Y.; Liu, M.; Wu, H.; Gao, W. A Photocleavable Amphiphilic Prodrug Self-Assembled Nanoparticles with Effective Anticancer Activity In Vitro. Nanomaterials 2019, 9, 860.

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