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Antimicrobial Applications of Clay Nanotube-Based Composites

Functional Aluminosilicate Nanomaterials Lab, Gubkin University, 119991 Moscow, Russian Federation
Bionanotechnology Lab, Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Republic of Tatarstan, Russian Federation
Institute for Micromanufacturing, Louisiana Tech University, Ruston, LA 71270, USA
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nanomaterials 2019, 9(5), 708;
Received: 16 April 2019 / Revised: 28 April 2019 / Accepted: 30 April 2019 / Published: 7 May 2019
(This article belongs to the Special Issue Nanotubes for Health, Environment and Cultural Heritages)
PDF [2815 KB, uploaded 13 May 2019]


Halloysite nanotubes with different outer surface/inner lumen chemistry (SiO2/Al2O3) are natural objects with a 50 nm diameter hollow cylindrical structure, which are able to carry functional compounds both inside and outside. They are promising for biological applications where their drug loading capacity combined with a low toxicity ensures the safe interaction of these nanomaterials with living cells. In this paper, the antimicrobial properties of the clay nanotube-based composites are reviewed, including applications in microbe-resistant biocidal textile, paints, filters, and medical formulations (wound dressings, drug delivery systems, antiseptic sprays, and tissue engineering scaffolds). Though halloysite-based antimicrobial materials have been widely investigated, their application in medicine needs clinical studies. This review suggests the scalable antimicrobial nano/micro composites based on natural tubule clays and outlines research and development perspectives in the field. View Full-Text
Keywords: antimicrobial composites; halloysite; clay nanotubes; biofouling; microbiology antimicrobial composites; halloysite; clay nanotubes; biofouling; microbiology

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Stavitskaya, A.; Batasheva, S.; Vinokurov, V.; Fakhrullina, G.; Sangarov, V.; Lvov, Y.; Fakhrullin, R. Antimicrobial Applications of Clay Nanotube-Based Composites. Nanomaterials 2019, 9, 708.

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