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Electrospun Nanofibers: Recent Applications in Drug Delivery and Cancer Therapy

1
Department of Organic Chemistry, Faculty of Science, University of Málaga, 29071 Málaga, Spain
2
Department of Chemistry of Pharmaceutical Science, Faculty of Pharmacy, Complutense University of Madrid, 28040 Madrid, Spain
3
Institute of Biopathology and Regenerative Medicine (IBIMER), Biomedical Research Center (CIBM), University of Granada, 18100 Granada, Spain
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Instituto de Investigación Biosanitaria ibs.GRANADA, 18012 Granada, Spain
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Department of Anatomy and Embryology, Faculty of Medicine, University of Granada, 18016 Granada, Spain
*
Author to whom correspondence should be addressed.
Nanomaterials 2019, 9(4), 656; https://doi.org/10.3390/nano9040656
Received: 11 March 2019 / Revised: 18 April 2019 / Accepted: 19 April 2019 / Published: 24 April 2019
(This article belongs to the Special Issue Electrospun Nanofibers for Biomedical Applications)
Polymeric nanofibers (NFs) have been extensively reported as a biocompatible scaffold to be specifically applied in several researching fields, including biomedical applications. The principal researching lines cover the encapsulation of antitumor drugs for controlled drug delivery applications, scaffolds structures for tissue engineering and regenerative medicine, as well as magnetic or plasmonic hyperthermia to be applied in the reduction of cancer tumors. This makes NFs useful as therapeutic implantable patches or mats to be implemented in numerous biomedical researching fields. In this context, several biocompatible polymers with excellent biocompatibility and biodegradability including poly lactic-co-glycolic acid (PLGA), poly butylcyanoacrylate (PBCA), poly ethylenglycol (PEG), poly (ε-caprolactone) (PCL) or poly lactic acid (PLA) have been widely used for the synthesis of NFs using the electrospun technique. Indeed, other types of polymers with stimuli-responsive capabilities has have recently reported for the fabrication of polymeric NFs scaffolds with relevant biomedical applications. Importantly, colloidal nanoparticles used as nanocarriers and non-biodegradable structures have been also incorporated by electrospinning into polymeric NFs for drug delivery applications and cancer treatments. In this review, we focus on the incorporation of drugs into polymeric NFs for drug delivery and cancer treatment applications. However, the principal novelty compared with previously reported publications is that we also focus on recent investigations concerning new strategies that increase drug delivery and cancer treatments efficiencies, such as the incorporation of colloidal nanoparticles into polymeric NFs, the possibility to fabricate NFs with the capability to respond to external environments, and finally, the synthesis of hybrid polymeric NFs containing carbon nanotubes, magnetic and gold nanoparticles, with magnetic and plasmonic hyperthermia applicability. View Full-Text
Keywords: electrospun nanofibers; cancer treatment; drug release; nanomedicine; biocompatible polymers; hyperthermia electrospun nanofibers; cancer treatment; drug release; nanomedicine; biocompatible polymers; hyperthermia
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MDPI and ACS Style

Contreras-Cáceres, R.; Cabeza, L.; Perazzoli, G.; Díaz, A.; López-Romero, J.M.; Melguizo, C.; Prados, J. Electrospun Nanofibers: Recent Applications in Drug Delivery and Cancer Therapy. Nanomaterials 2019, 9, 656. https://doi.org/10.3390/nano9040656

AMA Style

Contreras-Cáceres R, Cabeza L, Perazzoli G, Díaz A, López-Romero JM, Melguizo C, Prados J. Electrospun Nanofibers: Recent Applications in Drug Delivery and Cancer Therapy. Nanomaterials. 2019; 9(4):656. https://doi.org/10.3390/nano9040656

Chicago/Turabian Style

Contreras-Cáceres, Rafael, Laura Cabeza, Gloria Perazzoli, Amelia Díaz, Juan M. López-Romero, Consolación Melguizo, and Jose Prados. 2019. "Electrospun Nanofibers: Recent Applications in Drug Delivery and Cancer Therapy" Nanomaterials 9, no. 4: 656. https://doi.org/10.3390/nano9040656

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