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Boron Nitride Doped Polyhydroxyalkanoate/Chitosan Nanocomposite for Antibacterial and Biological Applications

1
Department of Maritime Science and Technology, Faculty of Defence Science and Technology, National Defence University of Malaysia, Kuala Lumpur 57000, Malaysia
2
Research Centre for Nano-Materials and Energy Technology (RCNMET), School of Science and Technology, Sunway University, Subang Jaya 47500, Malaysia
3
Department of Biological Sciences, School of Science and Technology, Sunway University, Subang Jaya 47500, Malaysia
4
Polymer Research Laboratory, Department of Chemistry, University of Malaya, Faculty of Science, Kuala Lumpur 50603, Malaysia
5
Applied Microbiology and Ecobiomaterial Research Laboratory, School of Biological Sciences, Universiti Sains Malaysia, Penang 11800, Malaysia
6
Department of Engineering, Lancaster University, Lancaster LA1 4YW, UK
*
Authors to whom correspondence should be addressed.
Nanomaterials 2019, 9(4), 645; https://doi.org/10.3390/nano9040645
Received: 14 March 2019 / Revised: 6 April 2019 / Accepted: 10 April 2019 / Published: 21 April 2019
(This article belongs to the Special Issue Recent Progress in Antimicrobial Nanomaterials)
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Abstract

The present research focused on the fabrication of biocompatible polyhydroxyalkanoate, chitosan, and hexagonal boron nitride incorporated (PHA/Ch-hBN) nanocomposites through a simple solvent casting technique. The fabricated nanocomposites were comprehensively characterized by Fourier transform infrared spectroscope (FT-IR), field emission scanning electroscope (FESEM), and elemental mapping and thermogravimetric analysis (TGA). The antibacterial activity of nanocomposites were investigated through time-kill method against multi drug resistant (MDR) microbes such as methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli (E. coli) K1 strains. In addition, nanocomposites have examined for their host cytotoxicity abilities using a Lactate dehydrogenase (LDH) assay against spontaneously immortalized human keratinocytes (HaCaT) cell lines. The results demonstrated highly significant antibacterial activity against MDR organisms and also significant cell viability as compared to the positive control. The fabricated PHA/Ch-hBN nanocomposite demonstrated effective antimicrobial and biocompatibility properties that would feasibly suit antibacterial and biomedical applications. View Full-Text
Keywords: boron nitride; chitosan; polyhydroxyalkanoate; nanocomposite; biocompatible; antibacterial boron nitride; chitosan; polyhydroxyalkanoate; nanocomposite; biocompatible; antibacterial
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Mukheem, A.; Shahabuddin, S.; Akbar, N.; Miskon, A.; Muhamad Sarih, N.; Sudesh, K.; Ahmed Khan, N.; Saidur, R.; Sridewi, N. Boron Nitride Doped Polyhydroxyalkanoate/Chitosan Nanocomposite for Antibacterial and Biological Applications. Nanomaterials 2019, 9, 645.

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