Regioselective DNA Modification and Directed Self-Assembly of Triangular Gold Nanoplates

Wang, Guoqing; Zhang, Yao; Liang, Xingguo; Takarada, Tohru; Maeda, Mizuo

doi:10.3390/nano9040581

Open AccessArticle

Regioselective DNA Modification and Directed Self-Assembly of Triangular Gold Nanoplates

by

Guoqing Wang

^1,2,3,*

,

Yao Zhang

²,

Xingguo Liang

^2,3

,

Tohru Takarada

^1,*

and

Mizuo Maeda

¹

Bioengineering Laboratory, RIKEN Cluster for Pioneering Research, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan

²

College of Food Science and Engineering, Ocean University of China, 5 Yushan Road, Qingdao 266003, China

³

Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China

^*

Authors to whom correspondence should be addressed.

Nanomaterials 2019, 9(4), 581; https://doi.org/10.3390/nano9040581

Submission received: 4 February 2019 / Revised: 11 March 2019 / Accepted: 28 March 2019 / Published: 9 April 2019

(This article belongs to the Special Issue Synthesis and Applications of Functionalized Gold Nanosystems)

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Abstract

As a class of emerging nanoparticles, gold nanotriangles (AuNTs) are characterized by unique structural anisotropy and plasmonic properties. The organization of AuNTs into well-defined architecture potentially promises collective properties that are difficult to produce by individual AuNTs. To date, however, the orientation-controlled self-assembly of AuNTs has been achieved with limited success. Here, we describe an effective and straightforward approach to induce directed self-assembly of AuNTs. By taking advantage of the uneven chemical reactivity of AuNT surfaces, we implement regioselective modification of the edges and the top/bottom surfaces with two different double-stranded DNA (dsDNA) sequences. By means of terminal single base pairing/unpairing, controlled assembly of the dsDNA-modified AuNTs evolves in a face-to-face or edge-to-edge manner based on blunt-end stacking interaction on an intentional region of the AuNTs, along with entropic repulsion by unpaired terminal nucleobases on the other region. This approach could be useful for achieving directed self-assembly of other anisotropic nanoparticles.

Keywords: DNA; gold; nanoplate; nanotriangle; regioselective modification; self-assembly

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MDPI and ACS Style

Wang, G.; Zhang, Y.; Liang, X.; Takarada, T.; Maeda, M. Regioselective DNA Modification and Directed Self-Assembly of Triangular Gold Nanoplates. Nanomaterials 2019, 9, 581. https://doi.org/10.3390/nano9040581

AMA Style

Wang G, Zhang Y, Liang X, Takarada T, Maeda M. Regioselective DNA Modification and Directed Self-Assembly of Triangular Gold Nanoplates. Nanomaterials. 2019; 9(4):581. https://doi.org/10.3390/nano9040581

Chicago/Turabian Style

Wang, Guoqing, Yao Zhang, Xingguo Liang, Tohru Takarada, and Mizuo Maeda. 2019. "Regioselective DNA Modification and Directed Self-Assembly of Triangular Gold Nanoplates" Nanomaterials 9, no. 4: 581. https://doi.org/10.3390/nano9040581

APA Style

Wang, G., Zhang, Y., Liang, X., Takarada, T., & Maeda, M. (2019). Regioselective DNA Modification and Directed Self-Assembly of Triangular Gold Nanoplates. Nanomaterials, 9(4), 581. https://doi.org/10.3390/nano9040581

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Regioselective DNA Modification and Directed Self-Assembly of Triangular Gold Nanoplates

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