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Article

CdSe/ZnS Quantum Dots Impaired the First Two Generations of Placenta Growth in an Animal Model, Based on the Shh Signaling Pathway

1
State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China
2
Zystein, LLC., Fayetteville, AR 72704, USA
*
Author to whom correspondence should be addressed.
Nanomaterials 2019, 9(2), 257; https://doi.org/10.3390/nano9020257
Received: 27 December 2018 / Revised: 7 February 2019 / Accepted: 11 February 2019 / Published: 14 February 2019
The toxicity, especially the transgenerational toxicity of quantum dots (QDs) in vivo, is still scarcely understood in spite of great promising applications of QDs in biomedicine. In this study, the maternal status, pregnancy outcome, and fetus development of parental generation (P0) to offspring in three generations (F3) were investigated after Kunming mice perinatal (GD 13-PND 5) exposure to Cd containing QDs (CdSe/ZnS QDs) and CdCl2. The results show CdSe/ZnS QDs induced placenta injuries in P0 and diminished placenta diameters in F1 and F2. Bodyweight growth decreased in the CdSe/ZnS QDs treatment group in the F1 and F2 generation. Additionally, CdSe/ZnS QDs significantly altered the expression of key genes in the Shh signal pathway. Overall, this study exhibited that the CdSe/ZnS QDs exposure during perinatal period impaired placenta growth in the first two generations, but not on the third generation. The toxicological actions of the CdSe/ZnS QDs might be through the effects on the Shh signal pathway. View Full-Text
Keywords: CdSe/ZnS QDs; multigenerational effects; placenta; Shh signal pathway CdSe/ZnS QDs; multigenerational effects; placenta; Shh signal pathway
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MDPI and ACS Style

Hong, W.; Kuang, H.; He, X.; Yang, L.; Yang, P.; Chen, B.; Aguilar, Z.P.; Xu, H. CdSe/ZnS Quantum Dots Impaired the First Two Generations of Placenta Growth in an Animal Model, Based on the Shh Signaling Pathway. Nanomaterials 2019, 9, 257. https://doi.org/10.3390/nano9020257

AMA Style

Hong W, Kuang H, He X, Yang L, Yang P, Chen B, Aguilar ZP, Xu H. CdSe/ZnS Quantum Dots Impaired the First Two Generations of Placenta Growth in an Animal Model, Based on the Shh Signaling Pathway. Nanomaterials. 2019; 9(2):257. https://doi.org/10.3390/nano9020257

Chicago/Turabian Style

Hong, Wuding, Huijuan Kuang, Xingping He, Lin Yang, Pengfei Yang, Bolu Chen, Zoraida P. Aguilar, and Hengyi Xu. 2019. "CdSe/ZnS Quantum Dots Impaired the First Two Generations of Placenta Growth in an Animal Model, Based on the Shh Signaling Pathway" Nanomaterials 9, no. 2: 257. https://doi.org/10.3390/nano9020257

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