Next Article in Journal
Evolution Mechanism of Photonically Sintered Nano-Silver Conductive Patterns
Previous Article in Journal
Synthesis and Characterization of Elongated-Shaped Silver Nanoparticles as a Biocompatible Anisotropic SERS Probe for Intracellular Imaging: Theoretical Modeling and Experimental Verification
Previous Article in Special Issue
Neurotoxicity of Nanomaterials: An Up-to-Date Overview
Article Menu
Issue 2 (February) cover image

Export Article

Open AccessArticle
Nanomaterials 2019, 9(2), 257; https://doi.org/10.3390/nano9020257

CdSe/ZnS Quantum Dots Impaired the First Two Generations of Placenta Growth in an Animal Model, Based on the Shh Signaling Pathway

1
State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China
2
Zystein, LLC., Fayetteville, AR 72704, USA
*
Author to whom correspondence should be addressed.
Received: 27 December 2018 / Revised: 7 February 2019 / Accepted: 11 February 2019 / Published: 14 February 2019
Full-Text   |   PDF [3446 KB, uploaded 14 February 2019]   |  

Abstract

The toxicity, especially the transgenerational toxicity of quantum dots (QDs) in vivo, is still scarcely understood in spite of great promising applications of QDs in biomedicine. In this study, the maternal status, pregnancy outcome, and fetus development of parental generation (P0) to offspring in three generations (F3) were investigated after Kunming mice perinatal (GD 13-PND 5) exposure to Cd containing QDs (CdSe/ZnS QDs) and CdCl2. The results show CdSe/ZnS QDs induced placenta injuries in P0 and diminished placenta diameters in F1 and F2. Bodyweight growth decreased in the CdSe/ZnS QDs treatment group in the F1 and F2 generation. Additionally, CdSe/ZnS QDs significantly altered the expression of key genes in the Shh signal pathway. Overall, this study exhibited that the CdSe/ZnS QDs exposure during perinatal period impaired placenta growth in the first two generations, but not on the third generation. The toxicological actions of the CdSe/ZnS QDs might be through the effects on the Shh signal pathway. View Full-Text
Keywords: CdSe/ZnS QDs; multigenerational effects; placenta; Shh signal pathway CdSe/ZnS QDs; multigenerational effects; placenta; Shh signal pathway
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Hong, W.; Kuang, H.; He, X.; Yang, L.; Yang, P.; Chen, B.; Aguilar, Z.P.; Xu, H. CdSe/ZnS Quantum Dots Impaired the First Two Generations of Placenta Growth in an Animal Model, Based on the Shh Signaling Pathway. Nanomaterials 2019, 9, 257.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nanomaterials EISSN 2079-4991 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top