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Preparation and Characterization of Biomimetic Hydroxyapatite Nanocrystals by Using Partially Hydrolyzed Keratin as Template Agent

School of Chemistry and Chemical Engineering, Yangzhou University, Jiangsu 225009, China
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Nanomaterials 2019, 9(2), 241; https://doi.org/10.3390/nano9020241
Received: 17 January 2019 / Revised: 25 January 2019 / Accepted: 30 January 2019 / Published: 11 February 2019
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Abstract

Hydroxyapatite (HA), a typical inorganic component of bone, is a widely utilized biomaterial for bone tissue repair and regeneration due to its excellent properties. Inspired by the recent findings on the important roles of protein in biomineralization and natural structure of fish scales, keratin was chosen as a template for modulating the assembly of HA nanocrystals. A series of HA nanocrystals with different sizes were synthesized by adjusting the concentration of partially hydrolyzed keratin. The structure and compositions of the prepared HA were characterized by Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), Raman spectrum, and Transmission electron microscopy (TEM). Results revealed that the size of the synthesized HA nanocrystals can be controlled by adjusting the concentration of partially hydrolyzed keratin. Specifically, the size of synthesized HA decreased from 63 ± 1.5 nm to 27 ± 0.9 nm with the increasing concentration of partially hydrolyzed keratin from 0 to 0.6g. In addition, in vitro cytocompatibility of synthesized HA nanocrystals were evaluated using the MG-63 cells. View Full-Text
Keywords: hydroxyapatite (HA); nanocrystal; hydrolyzed keratin; fish scales hydroxyapatite (HA); nanocrystal; hydrolyzed keratin; fish scales
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Gao, C.; Zhao, K.; Lin, L.; Wang, J.; Liu, Y.; Zhu, P. Preparation and Characterization of Biomimetic Hydroxyapatite Nanocrystals by Using Partially Hydrolyzed Keratin as Template Agent. Nanomaterials 2019, 9, 241.

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