Next Article in Journal
Intracellular Imaging with Genetically Encoded RNA-Based Molecular Sensors
Previous Article in Journal
Development of Solid Lipid Nanoparticles by Cold Dilution of Microemulsions: Curcumin Loading, Preliminary In Vitro Studies, and Biodistribution
Article Menu
Issue 2 (February) cover image

Export Article

Open AccessArticle
Nanomaterials 2019, 9(2), 232; https://doi.org/10.3390/nano9020232

The Contribution of Magnetic Nanoparticles to Ferrogel Biophysical Properties

1
Ural State Medical University, 620028 Ekaterinburg, Russia
2
Institute of Natural Sciences and Mathematics, Ural Federal University, 620002 Ekaterinburg, Russia
3
Ural Scientific Institute of Traumatology and Orthopaedics, 620014 Ekaterinburg, Russia
4
Center of Specialized Types of Medical Care Institute of Medical Cell Technologies, 620026 Ekaterinburg, Russia
5
Institute of Electrophysics, Ural Division RAS, 620016 Yekaterinburg, Russia
6
Advanced Research Facilities (SGIKER), Universidad del País Vasco UPV-EHU, 48080 Bilbao, Spain
7
Universidad del País Vasco UPV/EHU, Departamento de Electricidad y Electrónica and BCMaterials, 48080 Bilbao, Spain
*
Author to whom correspondence should be addressed.
Received: 2 January 2019 / Revised: 31 January 2019 / Accepted: 5 February 2019 / Published: 8 February 2019
Full-Text   |   PDF [5407 KB, uploaded 8 February 2019]   |  

Abstract

Iron oxide γ-Fe2O3 magnetic nanoparticles (MNPs) were fabricated by laser target evaporation technique (LTE) and their structure and magnetic properties were studied. Polyacrylamide (PAAm) gels with different cross-linking density of the polymer network and polyacrylamide-based ferrogel with embedded LTE MNPs (0.34 wt.%) were synthesized. Their adhesive and proliferative potential with respect to human dermal fibroblasts were studied. At the same value of Young modulus, the adhesive and proliferative activities of the human dermal fibroblasts on the surface of ferrogel were unexpectedly much higher in comparison with the surface of PAAm gel. Properties of PAAm-100 + γ-Fe2O3 MNPs composites were discussed with focus on creation of a new generation of drug delivery systems combined in multifunctional devices, including magnetic field assisted delivery, positioning, and biosensing. Although exact applications are still under development, the obtained results show a high potential of LTE MNPs to be applied for cellular technologies and tissue engineering. PAAm-100 ferrogel with very low concentration of γ-Fe2O3 MNPs results in significant improvement of the cells’ compatibility to the gel-based scaffold. View Full-Text
Keywords: iron oxide nanoparticles; polyacrylamide gels; ferrogels; dermal fibroblasts; cellular technologies; tissue engineering; biomedical applications; magnetic biosensing iron oxide nanoparticles; polyacrylamide gels; ferrogels; dermal fibroblasts; cellular technologies; tissue engineering; biomedical applications; magnetic biosensing
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Blyakhman, F.A.; Makarova, E.B.; Fadeyev, F.A.; Lugovets, D.V.; Safronov, A.P.; Shabadrov, P.A.; Shklyar, T.F.; Melnikov, G.Y.; Orue, I.; Kurlyandskaya, G.V. The Contribution of Magnetic Nanoparticles to Ferrogel Biophysical Properties. Nanomaterials 2019, 9, 232.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nanomaterials EISSN 2079-4991 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top