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Open AccessArticle

Facile Synthesis of Triangular and Hexagonal Anionic Gold Nanoparticles and Evaluation of Their Cytotoxicity

1
School of Pharmacy, Sungkyunkwan University, 2066 Seoburo, Jangan-gu, Suwon, Gyeonggido 16419, Korea
2
Amity Institute of Nanotechnology, Amity University Uttar Pradesh, Sector 125, Noida 201303, India
*
Author to whom correspondence should be addressed.
Nanomaterials 2019, 9(12), 1774; https://doi.org/10.3390/nano9121774
Received: 7 November 2019 / Revised: 21 November 2019 / Accepted: 9 December 2019 / Published: 12 December 2019
Comprehension of the shape-dependent properties of gold nanoparticles (AuNPs) could benefit the advancements in cellular uptake efficiency. Spherical AuNPs have generally been used for drug delivery, and recent research has indicated that the cellular uptake of triangular AuNPs was higher than that of spherical ones. Previous reports have also revealed that chemically synthesized AuNPs were cytotoxic. Therefore, we have developed a facile, cost-effective, and environmentally friendly method for synthesizing triangular and hexagonal anionic AuNPs. The zeta potential of the synthesized AuNPs was negative, which indicated that their surface could be easily functionalized with positively charged molecules to upload drugs or biomolecules. Transmission electron microscopy (TEM) images illustrated that the largest particle size of the synthesized quasi-hexagonal AuNPs was 61 nm. The TEM images also illustrated that two types of equilateral-triangular AuNPs were synthesized: One featured sharp and the other rounded corners. The sides of the smallest and largest triangular AuNPs were 23 and 178 nm, respectively. Energy-dispersive X-ray spectra of the green-synthesized AuNPs indicated that they consisted entirely of elemental Au. The cytotoxicity of the green-synthesized AuNPs was evaluated using 3T3-L1 adipocytes. Using cell viability data, we determined that the green-synthesized AuNPs did not exhibit any cytotoxic effects on 3T3-L1 adipocytes. View Full-Text
Keywords: green synthesis; Erigeron annuus leaf extract; gold nanoparticles; triangular and hexagonal; cytotoxicity; 3T3-L1 preadipocytes green synthesis; Erigeron annuus leaf extract; gold nanoparticles; triangular and hexagonal; cytotoxicity; 3T3-L1 preadipocytes
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Tripathi, R.M.; Yoon, S.-Y.; Ahn, D.; Chung, S.J. Facile Synthesis of Triangular and Hexagonal Anionic Gold Nanoparticles and Evaluation of Their Cytotoxicity. Nanomaterials 2019, 9, 1774.

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