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Open AccessArticle

An Nd3+-Sensitized Upconversion Fluorescent Sensor for Epirubicin Detection

Jiangsu Key Laboratory for Design & Manufacture of Micro/Nano Biomedical Instruments and School of Mechanical Engineering, Southeast University, Nanjing 210096, China
School of Public Health, Southeast University, Nanjing 210009, China
Authors to whom correspondence should be addressed.
Nanomaterials 2019, 9(12), 1700;
Received: 1 November 2019 / Revised: 23 November 2019 / Accepted: 26 November 2019 / Published: 28 November 2019
We describe here an Nd3+-sensitized upconversion fluorescent sensor for epirubicin (EPI) detection in aqueous solutions under 808 nm laser excitation. The upconversion fluorescence of nanoparticles is effectively quenched in the presence of EPI via a fluorescence resonance energy transfer mechanism. The dynamic quenching constant was 2.10 × 104 M−1. Normalized fluorescence intensity increased linearly as the EPI concentration was raised from 0.09 μM to 189.66 μM and the fluorometric detection limit was 0.05 μM. The sensing method was simple, fast, and low-cost and was able to be applied to determine the levels of EPI in urine with spike recoveries from 97.5% to 102.6%. Another important feature of the proposed fluorescent sensor is that it holds a promising potential for in vivo imaging and detection due to its distinctive properties such as weak autofluorescence, low heating effect, and high light penetration depth. View Full-Text
Keywords: upconversion; lanthanide doped nanoparticles; fluorescence; sensor; epirubicin upconversion; lanthanide doped nanoparticles; fluorescence; sensor; epirubicin
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MDPI and ACS Style

Mo, J.; Shen, L.; Xu, Q.; Zeng, J.; Sha, J.; Hu, T.; Bi, K.; Chen, Y. An Nd3+-Sensitized Upconversion Fluorescent Sensor for Epirubicin Detection. Nanomaterials 2019, 9, 1700.

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