An Nd3+-Sensitized Upconversion Fluorescent Sensor for Epirubicin Detection
by
Jingwen Mo 1,*, Long Shen 1, Qian Xu 2, Jiaying Zeng 2,*, Jingjie Sha 1
, Tao Hu 1, Kedong Bi 1 and Yunfei Chen 1,*
Jingwen Mo 1,*, Long Shen 1, Qian Xu 2, Jiaying Zeng 2,*, Jingjie Sha 1, Tao Hu 1, Kedong Bi 1 and Yunfei Chen 1,*
1
Jiangsu Key Laboratory for Design & Manufacture of Micro/Nano Biomedical Instruments and School of Mechanical Engineering, Southeast University, Nanjing 210096, China
2
School of Public Health, Southeast University, Nanjing 210009, China
*
Authors to whom correspondence should be addressed.
Nanomaterials 2019, 9(12), 1700; https://doi.org/10.3390/nano9121700
Received: 1 November 2019 / Revised: 23 November 2019 / Accepted: 26 November 2019 / Published: 28 November 2019
We describe here an Nd3+-sensitized upconversion fluorescent sensor for epirubicin (EPI) detection in aqueous solutions under 808 nm laser excitation. The upconversion fluorescence of nanoparticles is effectively quenched in the presence of EPI via a fluorescence resonance energy transfer mechanism. The dynamic quenching constant was 2.10 × 104 M−1. Normalized fluorescence intensity increased linearly as the EPI concentration was raised from 0.09 μM to 189.66 μM and the fluorometric detection limit was 0.05 μM. The sensing method was simple, fast, and low-cost and was able to be applied to determine the levels of EPI in urine with spike recoveries from 97.5% to 102.6%. Another important feature of the proposed fluorescent sensor is that it holds a promising potential for in vivo imaging and detection due to its distinctive properties such as weak autofluorescence, low heating effect, and high light penetration depth.
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Keywords:
upconversion; lanthanide doped nanoparticles; fluorescence; sensor; epirubicin
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MDPI and ACS Style
Mo, J.; Shen, L.; Xu, Q.; Zeng, J.; Sha, J.; Hu, T.; Bi, K.; Chen, Y. An Nd3+-Sensitized Upconversion Fluorescent Sensor for Epirubicin Detection. Nanomaterials 2019, 9, 1700.
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