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Nanomaterials 2018, 8(9), 730;

Analysis of Biomolecules Based on the Surface Enhanced Raman Spectroscopy

Shandong Provincial Key Laboratory of Animal Resistance Biology, Institute of Biomedical Sciences, Key Laboratory of Food Nutrition and Safety of Shandong Normal University, College of Life Science, Shandong Normal University, Jinan 250014, China
Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University (BTBU), Beijing 100048, China
Food, Nutrition and Health Program, Faculty of Land and Food Systems, The University of British Columbia, Vancouver, BC V6T 1Z4, Canada
Author to whom correspondence should be addressed.
Received: 28 August 2018 / Revised: 10 September 2018 / Accepted: 14 September 2018 / Published: 15 September 2018
PDF [4090 KB, uploaded 17 September 2018]


Analyzing biomolecules is essential for disease diagnostics, food safety inspection, environmental monitoring and pharmaceutical development. Surface-enhanced Raman spectroscopy (SERS) is a powerful tool for detecting biomolecules due to its high sensitivity, rapidness and specificity in identifying molecular structures. This review focuses on the SERS analysis of biomolecules originated from humans, animals, plants and microorganisms, combined with nanomaterials as SERS substrates and nanotags. Recent advances in SERS detection of target molecules were summarized with different detection strategies including label-free and label-mediated types. This comprehensive and critical summary of SERS analysis of biomolecules might help researchers from different scientific backgrounds spark new ideas and proposals. View Full-Text
Keywords: biomolecule; surface enhanced Raman spectroscopy (SERS); nanomaterial; analysis; identification; biology biomolecule; surface enhanced Raman spectroscopy (SERS); nanomaterial; analysis; identification; biology

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Jia, M.; Li, S.; Zang, L.; Lu, X.; Zhang, H. Analysis of Biomolecules Based on the Surface Enhanced Raman Spectroscopy. Nanomaterials 2018, 8, 730.

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