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Nanomaterials 2018, 8(9), 706;

Gold Rod-Polyethylene Glycol-Carbon Dot Nanohybrids as Phototheranostic Probes

Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 29 Zhongguancun East Road, Haidian District, Beijing 100190, China
Faculty of Engineering and Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan 52900, Israel
University of Chinese Academy of Sciences, 19A Yuquan Road, Shijingshan District, Beijing 100049, China
Authors to whom correspondence should be addressed.
Received: 21 August 2018 / Revised: 3 September 2018 / Accepted: 5 September 2018 / Published: 10 September 2018
(This article belongs to the Special Issue Nanosized Luminescent Materials: Advances and Applications)
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Emphasis using phototheranostics has been placed on the construction of multifunctional nanoplatforms for simultaneous tumor diagnosis and therapy. Herein, we put forth a novel nanosized luminescent material using the incorporation of red emissive carbon dots on gold nanorods through polyethylene glycol as a covalent linkage for dual-modal imaging and photothermal therapy. The novel nanohybrids, not only retain the optical properties of the gold nanorod and carbon dots, but also possess superior imaging performance in both confocal laser scanning microscopy and fluorescence lifetime imaging microscopy. The nanohybrids also exhibit excellent photothermal performance as phototheranostic nanohybrid probes for in vitro assays. This study promises a new multifunctional nanoplatform for cancer diagnostics and therapeutics. View Full-Text
Keywords: gold nanorod; carbon dots; nanohybrids; bioimaging; photothermal therapy gold nanorod; carbon dots; nanohybrids; bioimaging; photothermal therapy

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Niu, Y.; Ling, G.; Wang, L.; Guan, S.; Xie, Z.; Barnoy, E.A.; Zhou, S.; Fixler, D. Gold Rod-Polyethylene Glycol-Carbon Dot Nanohybrids as Phototheranostic Probes. Nanomaterials 2018, 8, 706.

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