Next Article in Journal
Facile Fabrication of Highly Active Magnetic Aminoclay Supported Palladium Nanoparticles for the Room Temperature Catalytic Reduction of Nitrophenol and Nitroanilines
Next Article in Special Issue
Enhanced Photodynamic Anticancer Activities of Multifunctional Magnetic Nanoparticles (Fe3O4) Conjugated with Chlorin e6 and Folic Acid in Prostate and Breast Cancer Cells
Previous Article in Journal
Optical Properties of Tensilely Strained Ge Nanomembranes
Article Menu
Issue 6 (June) cover image

Export Article

Version is current.

Open AccessArticle
Nanomaterials 2018, 8(6), 408; https://doi.org/10.3390/nano8060408

Dose- and Time-Dependent Cytotoxicity of Layered Black Phosphorus in Fibroblastic Cells

1
Department of Cogno-Mechatronics Engineering, College of Nanoscience & Nanotechnology, Pusan National University, Busan 46241, Korea
2
Research Center for Energy Convergence Technology, Pusan National University, Busan 46241, Korea
3
Advanced Nano-surface Research Group, Korea Basic Science Institute (KBSI), Daejeon 34133, Korea
4
Dental Life Science Research Institute, Seoul National University Dental Hospital, Seoul 03080, Korea
5
Department of Mechanical Engineering, Sejong University, Seoul 05006, Korea
The authors contributed equally.
*
Authors to whom correspondence should be addressed.
Received: 10 May 2018 / Revised: 31 May 2018 / Accepted: 4 June 2018 / Published: 6 June 2018
(This article belongs to the Special Issue The Two Faces of Nanomaterials: Toxicity and Bioactivity)
Full-Text   |   PDF [5579 KB, uploaded 8 June 2018]   |  

Abstract

Black phosphorus (BP) is a monolayer/multilayer two-dimensional (2D) nanomaterial, which has recently emerged as one of the most attractive 2D nanomaterials due to its fascinating physicochemical and optoelectronical properties. Layered BP may have promising applications in biomedical fields, such as drug delivery, photodynamic/photothermal therapy and bioimaging, although its intrinsic toxicity has not been fully elucidated yet. In the present study, the cytotoxicological effects of layered BP on both cell metabolic activity and membrane integrity were investigated. Layered BPs were prepared using a modified ultrasonication-assisted solution method, and their physicochemical properties were characterized. The dose- and time-dependent cytotoxicity of layered BP was assessed against L-929 fibroblasts. Our findings indicate that the cytotoxicity of BPs is proportionally dependent on their concentration and exposure time, which is affected by the oxidative stress-mediated enzyme activity reduction and membrane disruption. On the other hand, layered BPs did not exhibit significant cytotoxicity at concentrations lower than 4 μg/mL. Therefore, it is suggested that layered BPs can be effectively utilized as therapeutic delivery carriers and imaging agents. View Full-Text
Keywords: black phosphorus; 2D nanomaterial; cytotoxicity; biomedical application black phosphorus; 2D nanomaterial; cytotoxicity; biomedical application
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Song, S.-J.; Shin, Y.C.; Lee, H.U.; Kim, B.; Han, D.-W.; Lim, D. Dose- and Time-Dependent Cytotoxicity of Layered Black Phosphorus in Fibroblastic Cells. Nanomaterials 2018, 8, 408.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nanomaterials EISSN 2079-4991 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top