Cyclodextrin-Based Magnetic Nanoparticles for Cancer Therapy

Mrówczyński, Radosław; Jędrzak, Artur; Szutkowski, Kosma; Grześkowiak, Bartosz F.; Coy, Emerson; Markiewicz, Roksana; Jesionowski, Teofil; Jurga, Stefan

doi:10.3390/nano8030170

Open AccessArticle

Cyclodextrin-Based Magnetic Nanoparticles for Cancer Therapy

by

Radosław Mrówczyński

^1,*

,

Artur Jędrzak

^1,2,

Kosma Szutkowski

^1,*

,

Bartosz F. Grześkowiak

¹,

Emerson Coy

¹

,

Roksana Markiewicz

¹

,

Teofil Jesionowski

²

and

Stefan Jurga

¹

NanoBioMedical Centre, Adam Mickiewicz University in Poznan, Umultowska 85, PL-61614 Poznan, Poland

²

Faculty of Chemical Technology, Institute of Chemical Technology and Engineering, Poznan University of Technology, Berdychowo 4, PL-60965 Poznan, Poland

^*

Authors to whom correspondence should be addressed.

Nanomaterials 2018, 8(3), 170; https://doi.org/10.3390/nano8030170

Submission received: 23 January 2018 / Revised: 7 March 2018 / Accepted: 10 March 2018 / Published: 16 March 2018

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Abstract

Polydopamine (PDA)-coated magnetic nanoparticles functionalized with mono-6-thio-β-cyclodextrin (SH-βCD) were obtained and characterized by transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), Nuclear and Magnetic Resonance Imaging (NMR and MRI), and doxorubicin (DOXO)-loading experiments. The liver cancer cellular internalization of DOXO-loaded nanoparticles was investigated by confocal imaging microscopy. Synthesized nanomaterials bearing a chemotherapeutic drug and a layer of polydopamine capable of absorbing near-infrared light show high performance in the combined chemo- and photothermal therapy (CT-PTT) of liver cancer due to the synergistic effect of both modalities as demonstrated in vitro. Moreover, our material exhibits improved T₂ contrast properties, which have been verified using Carr-Purcell-Meiboom-Gill pulse sequence and MRI Spin-Echo imaging of the nanoparticles dispersed in the agarose gel phantoms. Therefore, the presented results cast new light on the preparation of polydopamine-based magnetic theranostic nanomaterials, as well as on the proper methodology for investigation of magnetic nanoparticles in high field MRI experiments. The prepared material is a robust theranostic nanoasystem with great potential in nanomedicine.

Keywords: magnetic nanoparticles; polydopamine; theranostic; MRI; nanomedicine

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MDPI and ACS Style

Mrówczyński, R.; Jędrzak, A.; Szutkowski, K.; Grześkowiak, B.F.; Coy, E.; Markiewicz, R.; Jesionowski, T.; Jurga, S. Cyclodextrin-Based Magnetic Nanoparticles for Cancer Therapy. Nanomaterials 2018, 8, 170. https://doi.org/10.3390/nano8030170

AMA Style

Mrówczyński R, Jędrzak A, Szutkowski K, Grześkowiak BF, Coy E, Markiewicz R, Jesionowski T, Jurga S. Cyclodextrin-Based Magnetic Nanoparticles for Cancer Therapy. Nanomaterials. 2018; 8(3):170. https://doi.org/10.3390/nano8030170

Chicago/Turabian Style

Mrówczyński, Radosław, Artur Jędrzak, Kosma Szutkowski, Bartosz F. Grześkowiak, Emerson Coy, Roksana Markiewicz, Teofil Jesionowski, and Stefan Jurga. 2018. "Cyclodextrin-Based Magnetic Nanoparticles for Cancer Therapy" Nanomaterials 8, no. 3: 170. https://doi.org/10.3390/nano8030170

APA Style

Mrówczyński, R., Jędrzak, A., Szutkowski, K., Grześkowiak, B. F., Coy, E., Markiewicz, R., Jesionowski, T., & Jurga, S. (2018). Cyclodextrin-Based Magnetic Nanoparticles for Cancer Therapy. Nanomaterials, 8(3), 170. https://doi.org/10.3390/nano8030170

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Cyclodextrin-Based Magnetic Nanoparticles for Cancer Therapy

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