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Open AccessArticle

Peptide-Templated Gold Clusters as Enzyme-Like Catalyst Boost Intracellular Oxidative Pressure and Induce Tumor-Specific Cell Apoptosis

Department of Chemistry and Chemical Engineering, Beijing University of Technology, No.100, Pingleyuan, Chaoyang District, Beijing 100124, China
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Nanomaterials 2018, 8(12), 1040; https://doi.org/10.3390/nano8121040
Received: 28 November 2018 / Revised: 8 December 2018 / Accepted: 9 December 2018 / Published: 12 December 2018
Anticancer metallodrugs that aim to physiological characters unique to tumor microenvironment are expected to combat drug tolerance and side-effects. Recently, owing to the fact that reactive oxygen species’ is closely related to the development of tumors, people are committed to developing metallodrugs with the capacity of improving the level of reactive oxygen species level toinduce oxidative stress in cancer cells. Herein, we demonstrated that peptide templated gold clusters with atomic precision preferably catalyze the transformation of hydrogen peroxide into superoxide anion in oxidative pressure-type tumor cells. Firstly, we successfully constructed gold clusters by rationally designing peptide sequences which targets integrin ανβ3 overexpressed on glioblastoma cells. The superoxide anion, radical derived from hydrogen peroxide and catalyzed by gold clusters, was confirmed in vitro under pseudo-physiological conditions. Then, kinetic parameters were evaluated to verify the catalytic properties of gold clusters. Furthermore, these peptide decorated clusters can serve as special enzyme-like catalyst to convert endogenous hydrogen peroxide into superoxide anion, elevated intracellular reactive oxygen species levels, lower mitochondrial membrane potential, damage biomacromolecules, and trigger tumor cell apoptosis consequently. View Full-Text
Keywords: gold clusters; biocatalysis; reactive oxygen species; oxidative pressure-type tumor gold clusters; biocatalysis; reactive oxygen species; oxidative pressure-type tumor
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Zhang, Y.; Zhang, X.; Yuan, Q.; Niu, W.; Zhang, C.; Li, J.; He, Z.; Tang, Y.; Ren, X.; Zhang, Z.; Cai, P.; Gao, L.; Gao, X. Peptide-Templated Gold Clusters as Enzyme-Like Catalyst Boost Intracellular Oxidative Pressure and Induce Tumor-Specific Cell Apoptosis. Nanomaterials 2018, 8, 1040.

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