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Open AccessArticle

Multifunctional Platform Based on Electroactive Polymers and Silica Nanoparticles for Tissue Engineering Applications

1
Centro/Departamento de Física, Universidade do Minho, 4710-057 Braga, Portugal
2
Centre of Molecular and Environmental Biology (CBMA), Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal
3
Centro de Química-Física Molecular and Institute of Nanosciences and Nanotechnology, Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal
4
Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal
5
CEB—Centre of Biological Engineering, Universidade do Minho, Campus de Gualtar, 4710 057 Braga, Portugal
6
Chemical Department and CQ-VR, Universidade de Trás-os-Montes e Alto Douro, 5001-801 Vila Real, Portugal
7
BCMaterials, Basque Centre for Materials, Applications and Nanostructures, UPV/EHU Science Park, 48940 Leioa, Spain
8
IKERBASQUE, Basque Foundation for Science, 48013 Bilbao, Spain
*
Author to whom correspondence should be addressed.
Nanomaterials 2018, 8(11), 933; https://doi.org/10.3390/nano8110933
Received: 25 October 2018 / Revised: 3 November 2018 / Accepted: 6 November 2018 / Published: 9 November 2018
(This article belongs to the Special Issue Nanocomposites of Polymers and Inorganic Nanoparticles)
Poly(vinylidene fluoride) nanocomposites processed with different morphologies, such as porous and non-porous films and fibres, have been prepared with silica nanoparticles (SiNPs) of varying diameter (17, 100, 160 and 300 nm), which in turn have encapsulated perylenediimide (PDI), a fluorescent molecule. The structural, morphological, optical, thermal, and mechanical properties of the nanocomposites, with SiNP filler concentration up to 16 wt %, were evaluated. Furthermore, cytotoxicity and cell proliferation studies were performed. All SiNPs are negatively charged independently of the pH and more stable from pH 5 upwards. The introduction of SiNPs within the polymer matrix increases the contact angle independently of the nanoparticle diameter. Moreover, the smallest ones (17 nm) also improve the PVDF Young’s modulus. The filler diameter, physico-chemical, thermal and mechanical properties of the polymer matrix were not significantly affected. Finally, the SiNPs’ inclusion does not induce cytotoxicity in murine myoblasts (C2C12) after 72 h of contact and proliferation studies reveal that the prepared composites represent a suitable platform for tissue engineering applications, as they allow us to combine the biocompatibility and piezoelectricity of the polymer with the possible functionalization and drug encapsulation and release of the SiNP. View Full-Text
Keywords: nanostructures; polymer matrix composites (PMCs); mechanical properties; thermal properties nanostructures; polymer matrix composites (PMCs); mechanical properties; thermal properties
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MDPI and ACS Style

Ribeiro, S.; Ribeiro, T.; Ribeiro, C.; Correia, D.M.; Farinha, J.P.S.; Gomes, A.C.; Baleizão, C.; Lanceros-Méndez, S. Multifunctional Platform Based on Electroactive Polymers and Silica Nanoparticles for Tissue Engineering Applications. Nanomaterials 2018, 8, 933.

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