Use of Polycaprolactone Electrospun Nanofibers as a Coating for Poly(methyl methacrylate) Bone Cement
Abstract
:1. Introduction
2. Results
2.1. Surface Topography
2.2. Cytocompatibility Properties
2.3. Mechanical Tests
3. Discussion
4. Materials and Methods
4.1. Materials
4.2. Sample Preparation
4.2.1. Sample Design
4.2.2. Sample Fabrication Process
(a) Fiber Production
(b) Surface Characterization and Mechanical Test Samples
(c) Cytocompatibility Test Samples
4.3. Experiments and Analysis
4.3.1. Surface Topography
4.3.2. Cell Adhesion, Proliferation, Mineralization, and Protein Adsorption Tests on PMMA Samples
4.3.3. Mechanical Tests
4.3.4. Statistical Analysis
5. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Descriptions | Control | ENF Coated | t | p-Value |
---|---|---|---|---|
Ra (μm) | 0.26 ± 0.03 | 2.75 ± 0.17 ** | 14.82 | 0.003 |
Rz (μm) | 1.45 ± 0.25 | 14.13 ± 1.24 ** | 10.02 | 0.008 |
Rsum (μm) | 75.47 ± 3.57 | 102.00 ± 6.30 * | 3.66 | 0.032 |
Parameters Descriptions | Control | ENF Coated | F1,56 | p-Value |
---|---|---|---|---|
No. of adhered cells after 2 days of cell culture | 232 ± 16 | 309 ± 12 * | 6.01 | 0.018 |
No. of adhered cells after 14 days of cell culture | 428 ± 53 | 615 ± 65 ** | 10.48 | 0.002 |
Parameters Descriptions | Control | ENF Coated | t | p-Value |
---|---|---|---|---|
Width of the sample | 1.97 ± 0.01 | 1.98 ± 0.03 | 0.23 | 0.83 |
Height of the sample | 1.49 ± 0.01 | 1.51 ± 0.01 | 1.31 | 0.20 |
Bending modulus (GPa) | 3.32 ± 0.11 | 3.30 ± 0.07 | 0.15 | 0.88 |
Bending strength (MPa) | 106.97 ± 4.94 | 108.12 ± 3.05 | 0.20 | 0.85 |
Maximum deflection (mm) | 1.56 ± 0.07 | 1.58 ± 0.04 | 0.15 | 0.88 |
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Share and Cite
Khandaker, M.; Riahinezhad, S.; Jamadagni, H.G.; Morris, T.L.; Coles, A.V.; Vaughan, M.B. Use of Polycaprolactone Electrospun Nanofibers as a Coating for Poly(methyl methacrylate) Bone Cement. Nanomaterials 2017, 7, 175. https://doi.org/10.3390/nano7070175
Khandaker M, Riahinezhad S, Jamadagni HG, Morris TL, Coles AV, Vaughan MB. Use of Polycaprolactone Electrospun Nanofibers as a Coating for Poly(methyl methacrylate) Bone Cement. Nanomaterials. 2017; 7(7):175. https://doi.org/10.3390/nano7070175
Chicago/Turabian StyleKhandaker, Morshed, Shahram Riahinezhad, Harsha G. Jamadagni, Tracy L. Morris, Alexis V. Coles, and Melville B. Vaughan. 2017. "Use of Polycaprolactone Electrospun Nanofibers as a Coating for Poly(methyl methacrylate) Bone Cement" Nanomaterials 7, no. 7: 175. https://doi.org/10.3390/nano7070175