Next Article in Journal
Silver Nanoparticles in Orthopedic Applications: New Insights on Their Effects on Osteogenic Cells
Previous Article in Journal
A Review of the Structure, Preparation, and Application of NLCs, PNPs, and PLNs
Article

Curcuma mangga-Mediated Synthesis of Gold Nanoparticles: Characterization, Stability, Cytotoxicity, and Blood Compatibility

1
Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
2
Low Dimensional Materials Research Centre (LDMRC), Department of Physics, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
3
Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia
4
Department of Physical Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai 625021, Tamil Nadu, India
*
Authors to whom correspondence should be addressed.
Academic Editor: Eva Pellicer
Nanomaterials 2017, 7(6), 123; https://doi.org/10.3390/nano7060123
Received: 4 March 2017 / Revised: 12 April 2017 / Accepted: 27 April 2017 / Published: 27 May 2017
The utilization of toxic chemicals as reducing and stabilizing agents in the preparation of gold nanoparticles (AuNPs) has increased in vivo toxicity and thus limited its application in clinical settings. Herein, we propose an alternative method of preparing highly stable AuNPs, where non-toxic Curcuma mangga (CM) extract was used as a single reducing and stabilizing agent to overcome the aforementioned constraints. The morphological images enunciated that the homogeneously dispersed AuNPs exhibited spherical morphology with an average particle diameter of 15.6 nm. Fourier Transform infrared (FTIR) and cyclic voltammetry analysis demonstrated that carbonyl groups of terpenoids in CM extract played an important role in the formation and stabilization of AuNPs. Green-synthesized AuNPs were found to have good stability in physiological media after 24 h of dispersion. The AuNPs were also cytocompatible with human colon fibroblast cell (CCD-18Co) and human lung fibroblast cell (MRC-5). Hemocompatibility tests revealed that the AuNPs were blood-compatible, with less than 10% of hemolysis without any aggregation of erythrocytes. The current study suggests potential in employing a CM-extract-based method in the preparation of AuNPs for anticancer diagnosis and therapy. View Full-Text
Keywords: gold nanoparticles; green synthesis; in vitro stability; biocompatible; phytochemicals; hemocompatibility gold nanoparticles; green synthesis; in vitro stability; biocompatible; phytochemicals; hemocompatibility
Show Figures

Graphical abstract

MDPI and ACS Style

Foo, Y.Y.; Periasamy, V.; Kiew, L.V.; Kumar, G.G.; Malek, S.N.A. Curcuma mangga-Mediated Synthesis of Gold Nanoparticles: Characterization, Stability, Cytotoxicity, and Blood Compatibility. Nanomaterials 2017, 7, 123. https://doi.org/10.3390/nano7060123

AMA Style

Foo YY, Periasamy V, Kiew LV, Kumar GG, Malek SNA. Curcuma mangga-Mediated Synthesis of Gold Nanoparticles: Characterization, Stability, Cytotoxicity, and Blood Compatibility. Nanomaterials. 2017; 7(6):123. https://doi.org/10.3390/nano7060123

Chicago/Turabian Style

Foo, Yiing Y., Vengadesh Periasamy, Lik V. Kiew, G. G. Kumar, and Sri N.A. Malek. 2017. "Curcuma mangga-Mediated Synthesis of Gold Nanoparticles: Characterization, Stability, Cytotoxicity, and Blood Compatibility" Nanomaterials 7, no. 6: 123. https://doi.org/10.3390/nano7060123

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop