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Open AccessFeature PaperReview

Lanthanide-Doped Nanoparticles for Diagnostic Sensing

by Song Yeul Lee 1, Min Lin 2,3, Aeju Lee 4,5 and Yong Il Park 1,*
1
School of Chemical Engineering, Chonnam National University, Gwangju 61186, Korea
2
The Key Laboratory of Biomedical Information Engineering, Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, China
3
Bioinspired Engineering and Biomechanics Center (BEBC), Xi’an Jiaotong University, Xi’an 710049, China
4
International Research Organization for Advance Science and Technology (IROAST), Kumamoto University, Kumamoto 860-8555, Japan
5
Magnesium Research Center, Kumamoto University, Kumamoto 860-8555, Japan
*
Author to whom correspondence should be addressed.
Nanomaterials 2017, 7(12), 411; https://doi.org/10.3390/nano7120411
Received: 9 October 2017 / Revised: 15 November 2017 / Accepted: 20 November 2017 / Published: 23 November 2017
(This article belongs to the Special Issue Nanomaterials for Sensing Applications)
Lanthanide-doped nanoparticles exhibit unique optical properties, such as a long luminescence lifetime (up to several milliseconds), sharp emission peaks, and upconversion luminescence over the range of wavelengths from near-infrared to visible. Exploiting these optical properties, lanthanide-doped nanoparticles have been widely utilized for cellular and small animal imaging with the absence of background autofluorescence. In addition, these nanoparticles have advantages of high signal-to-noise ratio for highly sensitive and selective diagnostic detection. In this review, we summarize and discuss recent progress in the development of highly sensitive diagnostic methods using lanthanide-doped nanoparticles. Combined with a smartphone, portable luminescence detecting platforms could be widely applied in point-of-care tests. View Full-Text
Keywords: lanthanide; upconversion; nanoparticles; diagnostics; sensing lanthanide; upconversion; nanoparticles; diagnostics; sensing
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MDPI and ACS Style

Lee, S.Y.; Lin, M.; Lee, A.; Park, Y.I. Lanthanide-Doped Nanoparticles for Diagnostic Sensing. Nanomaterials 2017, 7, 411.

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