Next Article in Journal
Potential Toxicity and Underlying Mechanisms Associated with Pulmonary Exposure to Iron Oxide Nanoparticles: Conflicting Literature and Unclear Risk
Next Article in Special Issue
Influence of Sterilization and Preservation Procedures on the Integrity of Serum Protein-Coated Magnetic Nanoparticles
Previous Article in Journal
Lyotropic Liquid Crystal Phases from Anisotropic Nanomaterials
Previous Article in Special Issue
Tuning Properties of Iron Oxide Nanoparticles in Aqueous Synthesis without Ligands to Improve MRI Relaxivity and SAR
Article Menu
Issue 10 (October) cover image

Export Article

Open AccessArticle

Surface Functionalization of Iron Oxide Nanoparticles with Gallic Acid as Potential Antioxidant and Antimicrobial Agents

1
Nanotechnology & Catalysis Research Centre (NANOCAT), University of Malaya, Block A, Level 3, Institute of Postgraduate Studies Building, Kuala Lumpur 50603, Malaysia
2
Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia
3
Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
*
Author to whom correspondence should be addressed.
Nanomaterials 2017, 7(10), 306; https://doi.org/10.3390/nano7100306
Received: 5 August 2017 / Revised: 28 August 2017 / Accepted: 30 August 2017 / Published: 5 October 2017
(This article belongs to the Special Issue Magnetic Nanoparticles in Biological Applications)
  |  
PDF [867 KB, uploaded 5 October 2017]
  |  

Abstract

In this research, we report the size-controlled synthesis and surface-functionalization of magnetite with the natural antioxidant gallic acid (GA) as a ligand, using in situ and post-synthesis methods. GA functionalization provided narrow size distribution, with an average particle size of 5 and 8 nm for in situ synthesis of gallic acid functionalized magnetite [email protected] and [email protected], respectively, which are ultra-small particles as compared to unfunctionalized magnetite (IONP) and post functionalized magnetite [email protected] with average size of 10 and 11 nm respectively. All the [email protected] samples were found hydrophilic with stable aggregation state. Prior to commencement of experimental lab work, PASS software was used to predict the biological activities of GA and it is found that experimental antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay and antimicrobial studies using well diffusion method are in good agreement with the simulated results. Furthermore, the half maximal inhibitory concentration (IC50) values of DPPH antioxidant assay revealed a 2–4 fold decrease as compared to unfunctionalized IONP. In addition to antioxidant activity, all the three [email protected] proved outstanding antimicrobial activity while testing on different bacterial and fungal strains. The results collectively indicate the successful fabrication of novel antioxidant, antimicrobial [email protected] composite, which are magnetically separable, efficient, and low cost, with potential applications in polymers, cosmetics, and biomedical and food industries. View Full-Text
Keywords: gallic acid; nanoantioxidant; DPPH; functionalization; antimicrobial gallic acid; nanoantioxidant; DPPH; functionalization; antimicrobial
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary materials

SciFeed

Share & Cite This Article

MDPI and ACS Style

Shah, S.T.; A Yehya, W.; Saad, O.; Simarani, K.; Chowdhury, Z.; A. Alhadi, A.; Al-Ani, L.A. Surface Functionalization of Iron Oxide Nanoparticles with Gallic Acid as Potential Antioxidant and Antimicrobial Agents. Nanomaterials 2017, 7, 306.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nanomaterials EISSN 2079-4991 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top