Poly-L-arginine Coated Silver Nanoprisms and Their Anti-Bacterial Properties
1
Department of Zoology, Government College University, Lahore 54000, Pakistan
2
Department of Chemical Engineering, University of Waterloo, Waterloo, ON N2L 3G1, Canada
*
Author to whom correspondence should be addressed.
Nanomaterials 2017, 7(10), 296; https://doi.org/10.3390/nano7100296
Received: 26 July 2017
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Revised: 13 September 2017
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Accepted: 22 September 2017
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Published: 27 September 2017
(This article belongs to the Special Issue Antibacterial Activity of Nanomaterials)
The aim of this study was to test the effect of two different morphologies of silver nanoparticles, spheres, and prisms, on their antibacterial properties when coated with poly-L-arginine (poly-Arg) to enhance the interactions with cells. Silver nanoparticle solutions were characterized by UV–visible spectroscopy, transmission electron microscopy, dynamic light scattering, zeta potential, as well as antimicrobial tests. These ultimately showed that a prismatic morphology exhibited stronger antimicrobial effects against Escherichia coli, Pseudomonas aeruginosa and Salmonella enterica. The minimum bactericidal concentration was found to be 0.65 μg/mL in the case of a prismatic AgNP-poly-Arg-PVP (silver nanoparticle-poly-L-arginine-polyvinylpyrrolidone) nanocomposite. The anticancer cell activity of the silver nanoparticles was also studied, where the maximum effect against a HeLa cell line was 80% mortality with a prismatic AgNP-poly-Arg-PVP nanocomposite at a concentration of 11 μg/mL. The antimicrobial activity of these silver nanocomposites demonstrates the potential of such coated silver nanoparticles in the area of nano-medicine.
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Keywords:
silver nanoparticles; anti-bacterial; poly-L-arginine; stability
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MDPI and ACS Style
Tanvir, F.; Yaqub, A.; Tanvir, S.; Anderson, W.A. Poly-L-arginine Coated Silver Nanoprisms and Their Anti-Bacterial Properties. Nanomaterials 2017, 7, 296. https://doi.org/10.3390/nano7100296
AMA Style
Tanvir F, Yaqub A, Tanvir S, Anderson WA. Poly-L-arginine Coated Silver Nanoprisms and Their Anti-Bacterial Properties. Nanomaterials. 2017; 7(10):296. https://doi.org/10.3390/nano7100296
Chicago/Turabian StyleTanvir, Fouzia, Atif Yaqub, Shazia Tanvir, and William A. Anderson. 2017. "Poly-L-arginine Coated Silver Nanoprisms and Their Anti-Bacterial Properties" Nanomaterials 7, no. 10: 296. https://doi.org/10.3390/nano7100296
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