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Article

Single Nano-Sized Metal–Organic Framework for Bio-Nanoarchitectonics with In Vivo Fluorescence Imaging and Chemo-Photodynamic Therapy

1
School of Advanced Materials and Nanotechnology, Academy of Advanced Interdisciplinary Research, Xidian University, Xi’an 710126, China
2
School of Life Sciences, Northwest University of Technology, Xi’an 710072, China
*
Author to whom correspondence should be addressed.
Academic Editor: Katsuhiko Ariga
Nanomaterials 2022, 12(2), 287; https://doi.org/10.3390/nano12020287
Received: 7 December 2021 / Revised: 6 January 2022 / Accepted: 9 January 2022 / Published: 17 January 2022
Theranostics is an emerging technique for cancer treatments due to its safety and high efficiency. However, the stability, efficiency, and convenience of preparation are the main challenges for developing theranostics. Here we describe a one-pot process for biocompatible metal–organic framework (MOF)-based theranostics. The ligand H2L designed for the MOF enables both red fluorescence emission and photodynamic therapy (PDT). The frame and regular channel structure of H2L-MOF empower the theranostics with good drug delivery performance, and the uniform and nano-sized particles facilitate the in vivo imaging/therapy applications. In vivo fluorescence imaging and in vitro chemo-photodynamic therapy were achieved with the MOF without any further modification. Our results reveal an effective strategy to achieve multifunctional theranostics by the synergistic action of the organic ligand, metal node, and channel structure of MOF nanoparticles. View Full-Text
Keywords: metal–organic framework (MOF); multifunction; fluorescence; chemotherapy; photodynamic therapy metal–organic framework (MOF); multifunction; fluorescence; chemotherapy; photodynamic therapy
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MDPI and ACS Style

Wang, Y.-M.; Xu, Y.; Zhang, X.; Cui, Y.; Liang, Q.; Liu, C.; Wang, X.; Wu, S.; Yang, R. Single Nano-Sized Metal–Organic Framework for Bio-Nanoarchitectonics with In Vivo Fluorescence Imaging and Chemo-Photodynamic Therapy. Nanomaterials 2022, 12, 287. https://doi.org/10.3390/nano12020287

AMA Style

Wang Y-M, Xu Y, Zhang X, Cui Y, Liang Q, Liu C, Wang X, Wu S, Yang R. Single Nano-Sized Metal–Organic Framework for Bio-Nanoarchitectonics with In Vivo Fluorescence Imaging and Chemo-Photodynamic Therapy. Nanomaterials. 2022; 12(2):287. https://doi.org/10.3390/nano12020287

Chicago/Turabian Style

Wang, Yong-Mei, Ying Xu, Xinxin Zhang, Yifan Cui, Qingquan Liang, Cunshun Liu, Xinan Wang, Shuqi Wu, and Rusen Yang. 2022. "Single Nano-Sized Metal–Organic Framework for Bio-Nanoarchitectonics with In Vivo Fluorescence Imaging and Chemo-Photodynamic Therapy" Nanomaterials 12, no. 2: 287. https://doi.org/10.3390/nano12020287

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