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Article

Application of Micro/Nanoporous Fluoropolymers with Reduced Bioadhesion in Digital Microfluidics

1
Laboratory of Process Technology, NeptunLab, Department of Microsystem Engineering (IMTEK), University of Freiburg, 79110 Freiburg im Breisgau, Germany
2
Freiburg Materials Research Center (FMF), University of Freiburg, 79104 Freiburg im Breisgau, Germany
3
Freiburg Center of Interactive Materials and Bioinspired Technologies (FIT), University of Freiburg, 79110 Freiburg im Breisgau, Germany
*
Author to whom correspondence should be addressed.
Academic Editors: Grzegorz Sulka, Agnieszka Brzózka, Magdalena Jarosz and Karolina Syrek
Nanomaterials 2022, 12(13), 2201; https://doi.org/10.3390/nano12132201
Received: 30 May 2022 / Revised: 24 June 2022 / Accepted: 25 June 2022 / Published: 27 June 2022
(This article belongs to the Special Issue Functional Nanostructured Materials—from Synthesis to Applications)
Digital microfluidics (DMF) is a versatile platform for conducting a variety of biological and chemical assays. The most commonly used set-up for the actuation of microliter droplets is electrowetting on dielectric (EWOD), where the liquid is moved by an electrostatic force on a dielectric layer. Superhydrophobic materials are promising materials for dielectric layers, especially since the minimum contact between droplet and surface is key for low adhesion of biomolecules, as it causes droplet pinning and cross contamination. However, superhydrophobic surfaces show limitations, such as full wetting transition between Cassie and Wenzel under applied voltage, expensive and complex fabrication and difficult integration into already existing devices. Here we present Fluoropor, a superhydrophobic fluorinated polymer foam with pores on the micro/nanoscale as a dielectric layer in DMF. Fluoropor shows stable wetting properties with no significant changes in the wetting behavior, or full wetting transition, until potentials of 400 V. Furthermore, Fluoropor shows low attachment of biomolecules to the surface upon droplet movement. Due to its simple fabrication process, its resistance to adhesion of biomolecules and the fact it is capable of being integrated and exchanged as thin films into commercial DMF devices, Fluoropor is a promising material for wide application in DMF. View Full-Text
Keywords: superhydrophobic; digital microfluidics; micro/nanoporous; low bio-adhesion; EWOD; DMF superhydrophobic; digital microfluidics; micro/nanoporous; low bio-adhesion; EWOD; DMF
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MDPI and ACS Style

Goralczyk, A.; Bhagwat, S.; Mayoussi, F.; Nekoonam, N.; Sachsenheimer, K.; Hou, P.; Kotz-Helmer, F.; Helmer, D.; Rapp, B.E. Application of Micro/Nanoporous Fluoropolymers with Reduced Bioadhesion in Digital Microfluidics. Nanomaterials 2022, 12, 2201. https://doi.org/10.3390/nano12132201

AMA Style

Goralczyk A, Bhagwat S, Mayoussi F, Nekoonam N, Sachsenheimer K, Hou P, Kotz-Helmer F, Helmer D, Rapp BE. Application of Micro/Nanoporous Fluoropolymers with Reduced Bioadhesion in Digital Microfluidics. Nanomaterials. 2022; 12(13):2201. https://doi.org/10.3390/nano12132201

Chicago/Turabian Style

Goralczyk, Andreas, Sagar Bhagwat, Fadoua Mayoussi, Niloofar Nekoonam, Kai Sachsenheimer, Peilong Hou, Frederik Kotz-Helmer, Dorothea Helmer, and Bastian E. Rapp. 2022. "Application of Micro/Nanoporous Fluoropolymers with Reduced Bioadhesion in Digital Microfluidics" Nanomaterials 12, no. 13: 2201. https://doi.org/10.3390/nano12132201

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