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Article

Silver Nanoparticles Stabilized with Phosphorus-Containing Heterocyclic Surfactants: Synthesis, Physico-Chemical Properties, and Biological Activity Determination

1
Department of Chemical Theory of Drugs, Faculty of Pharmacy, Comenius University, SK-83232 Bratislava, Slovakia
2
Department of Analytical Chemistry, Faculty of Natural Sciences, Comenius University, SK-84215 Bratislava, Slovakia
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Department of Cell and Molecular Biology of Drugs, Faculty of Pharmacy, Comenius University, SK-83232 Bratislava, Slovakia
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Faculty of Pharmacy, Comenius University, SK-83232 Bratislava, Slovakia
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Comenius University, SK-81499 Bratislava, Slovakia
6
Materials Research Centre, Faculty of Chemistry, University of Technology, CZ-61200 Brno, Czech Republic
*
Author to whom correspondence should be addressed.
Academic Editor: Ovidio Bussolati
Nanomaterials 2021, 11(8), 1883; https://doi.org/10.3390/nano11081883
Received: 2 June 2021 / Revised: 13 July 2021 / Accepted: 19 July 2021 / Published: 22 July 2021
(This article belongs to the Special Issue Nanomaterials and Nanotechnology Meeting 2021)
Phosphorus-containing heterocyclic cationic surfactants alkyldimethylphenylphospholium bromides with the alkyl chain length 14 to 18 carbon atoms were used for the stabilization of silver nanodispersions. Zeta potential of silver nanodispersions ranges from +35 to +70 mV, which indicates the formation of stable silver nanoparticles (AgNPs). Long-chain heptadecyl and octadecyl homologs of the surfactants series provided the most intensive stabilizing effect to AgNPs, resulting in high positive zeta potential values and smaller diameter of AgNPs in the range 50–60 nm. A comparison with non-heterocyclic alkyltrimethylphosphonium surfactants of the same alkyl chain length showed better stability and more positive zeta potential values for silver nanodispersions stabilized with heterocyclic phospholium surfactants. Investigations of biological activity of phospholium-capped AgNPs are represented by the studies of antimicrobial activity and cytotoxicity. While cytotoxicity results revealed an increased level of HepG2 cell growth inhibition as compared with the cytotoxicity level of silver-free surfactant solutions, no enhanced antimicrobial action of phospholium-capped AgNPs against microbial pathogens was observed. The comparison of cytotoxicity of AgNPs stabilized with various non-heterocyclic ammonium and phosphonium surfactants shows that AgNPs capped with heterocyclic alkyldimethylphenylphospholium and non-heterocyclic triphenyl-substituted phosphonium surfactants have the highest cytotoxicity among silver nanodispersions stabilized by the series of ammonium and phosphonium surfactants. View Full-Text
Keywords: phosphonium; silver nanoparticles; dynamic light scattering; zeta potential; Hep G2 cells; cytotoxicity phosphonium; silver nanoparticles; dynamic light scattering; zeta potential; Hep G2 cells; cytotoxicity
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MDPI and ACS Style

Pisárčik, M.; Lukáč, M.; Jampílek, J.; Bilka, F.; Bilková, A.; Pašková, Ľ.; Devínsky, F.; Horáková, R.; Březina, M.; Opravil, T. Silver Nanoparticles Stabilized with Phosphorus-Containing Heterocyclic Surfactants: Synthesis, Physico-Chemical Properties, and Biological Activity Determination. Nanomaterials 2021, 11, 1883. https://doi.org/10.3390/nano11081883

AMA Style

Pisárčik M, Lukáč M, Jampílek J, Bilka F, Bilková A, Pašková Ľ, Devínsky F, Horáková R, Březina M, Opravil T. Silver Nanoparticles Stabilized with Phosphorus-Containing Heterocyclic Surfactants: Synthesis, Physico-Chemical Properties, and Biological Activity Determination. Nanomaterials. 2021; 11(8):1883. https://doi.org/10.3390/nano11081883

Chicago/Turabian Style

Pisárčik, Martin, Miloš Lukáč, Josef Jampílek, František Bilka, Andrea Bilková, Ľudmila Pašková, Ferdinand Devínsky, Renáta Horáková, Matěj Březina, and Tomáš Opravil. 2021. "Silver Nanoparticles Stabilized with Phosphorus-Containing Heterocyclic Surfactants: Synthesis, Physico-Chemical Properties, and Biological Activity Determination" Nanomaterials 11, no. 8: 1883. https://doi.org/10.3390/nano11081883

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