Next Article in Journal
Cellulose Nanocrystals vs. Cellulose Nanofibers: A Comparative Study of Reinforcing Effects in UV-Cured Vegetable Oil Nanocomposites
Next Article in Special Issue
Nanopore Technology for the Application of Protein Detection
Previous Article in Journal
Recent Progress in Nanotechnology for COVID-19 Prevention, Diagnostics and Treatment
Previous Article in Special Issue
Electrochemical Performance of Titania 3D Nanonetwork Electrodes Induced by Pulse Ionization at Varied Pulse Repetitions
Article

Rapid Formation of Nanoclusters for Detection of Drugs in Urine Using Surface-Enhanced Raman Spectroscopy

1
Institute of Biophotonics, National Yang Ming Chiao Tung University, Taipei 112, Taiwan
2
Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei 106, Taiwan
*
Author to whom correspondence should be addressed.
Academic Editors: Mohsen Rahmani, Cuifeng Ying and Lei Xu
Nanomaterials 2021, 11(7), 1789; https://doi.org/10.3390/nano11071789
Received: 9 June 2021 / Revised: 1 July 2021 / Accepted: 7 July 2021 / Published: 9 July 2021
(This article belongs to the Special Issue Nanomaterials for Optical Bio/Chemical Sensing)
We developed a method based on surface-enhanced Raman spectroscopy (SERS) and a sample pretreatment process for rapid, sensitive, reproducible, multiplexed, and low-cost detection of illegal drugs in urine. The abuse of new psychoactive substances (NPS) has become an increasingly serious problem in many countries. However, immunoassay-based screening kits for NPS are usually not available because of the lack of corresponding antibodies. SERS has a great potential for rapid detection of NPS because it can simultaneously detect multiple kinds of drugs without the use of antibodies. To achieve highly sensitive SERS detection of drugs, sodium bromide was first employed to induce the rapid formation of Ag nanoclusters by aggregating silver nanoparticles (AgNPs) in the extracted sample solution. SERS measurements were performed immediately after the sample pretreatment without incubation. The three-dimensional SERS hot spots were believed to form significantly within the nanoclusters, providing strong SERS enhancement effects. The displacement of citrate molecules on the surfaces of the AgNPs by bromide ions helped increase the adsorption of drug molecules, increasing their areal density. We demonstrated the simultaneous detection of two kinds of NPS, methcathinone and 4-methylmethcathinone, in urine at a concentration as low as 0.01 ppm. View Full-Text
Keywords: surface-enhanced Raman spectroscopy (SERS); drug; new psychoactive substance; urine; nanocluster surface-enhanced Raman spectroscopy (SERS); drug; new psychoactive substance; urine; nanocluster
Show Figures

Graphical abstract

MDPI and ACS Style

Chen, Y.-C.; Hong, S.-W.; Wu, H.-H.; Wang, Y.-L.; Chen, Y.-F. Rapid Formation of Nanoclusters for Detection of Drugs in Urine Using Surface-Enhanced Raman Spectroscopy. Nanomaterials 2021, 11, 1789. https://doi.org/10.3390/nano11071789

AMA Style

Chen Y-C, Hong S-W, Wu H-H, Wang Y-L, Chen Y-F. Rapid Formation of Nanoclusters for Detection of Drugs in Urine Using Surface-Enhanced Raman Spectroscopy. Nanomaterials. 2021; 11(7):1789. https://doi.org/10.3390/nano11071789

Chicago/Turabian Style

Chen, Yun-Chu, Shang-Wen Hong, Huang-Hesin Wu, Yuh-Lin Wang, and Yih-Fan Chen. 2021. "Rapid Formation of Nanoclusters for Detection of Drugs in Urine Using Surface-Enhanced Raman Spectroscopy" Nanomaterials 11, no. 7: 1789. https://doi.org/10.3390/nano11071789

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop