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Article

Chelidoniummajus L. Incorporated Emulsion Electrospun PCL/PVA_PEC Nanofibrous Meshes for Antibacterial Wound Dressing Applications

1
FibEnTech Research Unit, Faculty of Engineering, University of Beira Interior, 6201 001 Covilhã, Portugal
2
Faculty of Technology and WANDER Nordic Water and Materials Institute, Satakunta University of Applied Sciences, 26101 Rauma, Finland
3
Centre for Textile Science and Technology (2C2T), University of Minho, 4800 058 Guimarães, Portugal
*
Author to whom correspondence should be addressed.
Academic Editor: Takuya Kitaoka
Nanomaterials 2021, 11(7), 1785; https://doi.org/10.3390/nano11071785
Received: 16 June 2021 / Revised: 5 July 2021 / Accepted: 7 July 2021 / Published: 9 July 2021
(This article belongs to the Special Issue Antimicrobial Nano Coatings)
Presently, there are many different types of wound dressings available on the market. Nonetheless, there is still a great interest to improve the performance and efficiency of these materials. Concerning that, new dressing materials containing natural products, such as medicinal plants that protect the wound from infections but also enhance skin regeneration have been or are being developed. Herein, we used for the first time a needleless emulsion electrospinning technique for incorporating Chelidoniummajus L. (C. majus), a medicinal plant widely known for its traditional therapeutic properties, in Polycaprolactone (PCL)/Polyvinyl Alcohol (PVA)_Pectin (PEC) nanofibrous meshes. Moreover, the potential use of these electrospun nanofibers as a carrier for C. majus was also explored. The results obtained revealed that the produced PCL/PVA_PEC nanofibrous meshes containing C. majus extract displayed morphological characteristics similar to the natural extracellular matrix of the skin (ECM). Furthermore, the produced meshes showed beneficial properties to support the healing process. Additionally, the C. majus-loaded PCL/PVA_PEC nanofibrous meshes inhibited Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa) growth, reaching a 3.82 Log reduction, and showed to be useful for controlled release, without causing any cytotoxic effect on the normal human dermal fibroblasts (NHDF) cells. Hence, these findings suggest the promising suitability of this novel wound dressing material for prevention and treatment of bacterial wound infections. View Full-Text
Keywords: emulsion electrospinning; needleless electrospinning; natural compounds; C. majus; antimicrobial wound dressing emulsion electrospinning; needleless electrospinning; natural compounds; C. majus; antimicrobial wound dressing
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MDPI and ACS Style

Mouro, C.; Gomes, A.P.; Ahonen, M.; Fangueiro, R.; Gouveia, I.C. Chelidoniummajus L. Incorporated Emulsion Electrospun PCL/PVA_PEC Nanofibrous Meshes for Antibacterial Wound Dressing Applications. Nanomaterials 2021, 11, 1785. https://doi.org/10.3390/nano11071785

AMA Style

Mouro C, Gomes AP, Ahonen M, Fangueiro R, Gouveia IC. Chelidoniummajus L. Incorporated Emulsion Electrospun PCL/PVA_PEC Nanofibrous Meshes for Antibacterial Wound Dressing Applications. Nanomaterials. 2021; 11(7):1785. https://doi.org/10.3390/nano11071785

Chicago/Turabian Style

Mouro, Cláudia, Ana P. Gomes, Merja Ahonen, Raul Fangueiro, and Isabel C. Gouveia 2021. "Chelidoniummajus L. Incorporated Emulsion Electrospun PCL/PVA_PEC Nanofibrous Meshes for Antibacterial Wound Dressing Applications" Nanomaterials 11, no. 7: 1785. https://doi.org/10.3390/nano11071785

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