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A Hyaluronic Acid Functionalized Self-Nano-Emulsifying Drug Delivery System (SNEDDS) for Enhancement in Ciprofloxacin Targeted Delivery against Intracellular Infection

Multi-Functional Core-Shell Nanofibers for Wound Healing

Hubei Key Laboratory of Digital Textile Equipment, Wuhan Textile University, Wuhan 430073, China
Institute for Frontier Materials, Deakin University, Geelong, VIC 3216, Australia
Foshan Green Intelligent Manufacturing Research Institute of Xiangtan University, Foshan 528000, China
South Subtropical Crop Research Institute, Chinese Academy of Tropical Agricultural Sciences, Zhanjiang 524091, China
Agricultural Product Processing Research Institute, Chinese Academy of Tropical Agricultural Sciences, Zhanjiang 524001, China
Authors to whom correspondence should be addressed.
Academic Editors: Dipak K. Sarker and Abdelhamid Elaissari
Nanomaterials 2021, 11(6), 1546;
Received: 8 May 2021 / Revised: 28 May 2021 / Accepted: 9 June 2021 / Published: 11 June 2021
Core-shell nanofibers have great potential for bio-medical applications such as wound healing dressings where multiple drugs and growth factors are expected to be delivered at different healing phases. Compared to monoaxial nanofibers, core-shell nanofibers can control the drug release profile easier, providing sustainable and effective drugs and growth factors for wound healing. However, it is challenging to produce core-shell structured nanofibers with a high production rate at low energy consumption. Co-axial centrifugal spinning is an alternative method to address the above limitations to produce core-shell nanofibers effectively. In this study, a co-axial centrifugal spinning device was designed and assembled to produce core-shell nanofibers for controlling the release rate of ibuprofen and hEGF in inflammation and proliferation phases during the wound healing process. Core-shell structured nanofibers were confirmed by TEM. This work demonstrated that the co-axial centrifugal spinning is a high productivity process that can produce materials with a 3D environment mimicking natural tissue scaffold, and the specific drug can be loaded into different layers to control the drug release rate to improve the drug efficiency and promote wound healing. View Full-Text
Keywords: core-shell nanofiber; drug delivery; co-axial centrifugal spinning; wound healing core-shell nanofiber; drug delivery; co-axial centrifugal spinning; wound healing
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MDPI and ACS Style

Li, Z.; Mei, S.; Dong, Y.; She, F.; Li, P.; Li, Y.; Kong, L. Multi-Functional Core-Shell Nanofibers for Wound Healing. Nanomaterials 2021, 11, 1546.

AMA Style

Li Z, Mei S, Dong Y, She F, Li P, Li Y, Kong L. Multi-Functional Core-Shell Nanofibers for Wound Healing. Nanomaterials. 2021; 11(6):1546.

Chicago/Turabian Style

Li, Zhen, Shunqi Mei, Yajie Dong, Fenghua She, Puwang Li, Yongzhen Li, and Lingxue Kong. 2021. "Multi-Functional Core-Shell Nanofibers for Wound Healing" Nanomaterials 11, no. 6: 1546.

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