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Article

Precipitation at Room Temperature as a Fast and Versatile Method for Calcium Phosphate/TiO2 Nanocomposites Synthesis

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Laboratory for Biocolloids and Surface Chemistry, Ruđer Bošković Institute, Bijenička Cesta 54, 10000 Zagreb, Croatia
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Laboratory for Energy Conversion Materials and Sensors, Ruđer Bošković Institute, Bijenička Cesta 54, 10000 Zagreb, Croatia
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Institute of Physics, Bijenička Cesta 46, 10000 Zagreb, Croatia
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Department of Histology and Embryology, School of Medicine, University of Zagreb, Šalata 3, 10000 Zagreb, Croatia
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Laboratory for Precipitation Processes, Ruđer Bošković Institute, Bijenička Cesta 54, 10000 Zagreb, Croatia
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Laboratory for Magnetic Resonances, Ruđer Bošković Institute, Bijenička Cesta 54, 10000 Zagreb, Croatia
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Institute for Medical Research and Occupational Health, Ksaverska Cesta 2, 10000 Zagreb, Croatia
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Author to whom correspondence should be addressed.
Academic Editors: Maria Violetta Brundo and Pablo del Pino
Nanomaterials 2021, 11(6), 1523; https://doi.org/10.3390/nano11061523
Received: 20 April 2021 / Revised: 24 May 2021 / Accepted: 7 June 2021 / Published: 9 June 2021
(This article belongs to the Special Issue Nano-TiO2: Characterization and Application)
The constantly growing need for advanced bone regeneration materials has motivated the development of calcium phosphates (CaPs) composites with a different metal or metal-oxide nanomaterials and their economical and environmentally friendly production. Here, two procedures for the synthesis of CaPs composites with TiO2 nanoplates (TiNPl) and nanowires (TiNWs) were tested, with the immersion of TiO2 nanomaterials (TiNMs) in corrected simulated body fluid (c-SBF) and precipitation of CaP in the presence of TiNMs. The materials obtained were analyzed by powder X-ray diffraction, spectroscopic and microscopic techniques, Brunauer–Emmett–Teller surface area analysis, thermogravimetric analysis, dynamic and electrophoretic light scattering, and their hemocompatibility and ability to induce reactive oxygen species were evaluated. After 28 days of immersion in c-SBF, no significant CaP coating was formed on TiNMs. However, the composites with calcium-deficient apatite (CaDHA) were obtained after one hour in the spontaneous precipitation system. In the absence of TiNMs, CaDHA was also formed, indicating that control of the CaP phase formed can be accomplished by fine-tuning conditions in the precipitation system. Although the morphology and size of crystalline domains of CaDHA obtained on the different nanomaterials differed, no significant difference was detected in their local structure. Composites showed low reactive oxygen species (ROS) production and did not induce hemolysis. The results obtained indicate that precipitation is a suitable and fast method for the preparation of CaPs/TiNMs nanocomposites which shows great potential for biomedical applications. View Full-Text
Keywords: calcium phosphates; TiO2 nanoplates; TiO2 nanowires; precipitation; simulated body fluid; reactive oxygen species; hemocompatibility calcium phosphates; TiO2 nanoplates; TiO2 nanowires; precipitation; simulated body fluid; reactive oxygen species; hemocompatibility
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MDPI and ACS Style

Erceg, I.; Selmani, A.; Gajović, A.; Radatović, B.; Šegota, S.; Ćurlin, M.; Strasser, V.; Kontrec, J.; Kralj, D.; Maltar-Strmečki, N.; Barbir, R.; Pem, B.; Vinković Vrček, I.; Dutour Sikirić, M. Precipitation at Room Temperature as a Fast and Versatile Method for Calcium Phosphate/TiO2 Nanocomposites Synthesis. Nanomaterials 2021, 11, 1523. https://doi.org/10.3390/nano11061523

AMA Style

Erceg I, Selmani A, Gajović A, Radatović B, Šegota S, Ćurlin M, Strasser V, Kontrec J, Kralj D, Maltar-Strmečki N, Barbir R, Pem B, Vinković Vrček I, Dutour Sikirić M. Precipitation at Room Temperature as a Fast and Versatile Method for Calcium Phosphate/TiO2 Nanocomposites Synthesis. Nanomaterials. 2021; 11(6):1523. https://doi.org/10.3390/nano11061523

Chicago/Turabian Style

Erceg, Ina, Atiđa Selmani, Andreja Gajović, Borna Radatović, Suzana Šegota, Marija Ćurlin, Vida Strasser, Jasminka Kontrec, Damir Kralj, Nadica Maltar-Strmečki, Rinea Barbir, Barbara Pem, Ivana Vinković Vrček, and Maja Dutour Sikirić. 2021. "Precipitation at Room Temperature as a Fast and Versatile Method for Calcium Phosphate/TiO2 Nanocomposites Synthesis" Nanomaterials 11, no. 6: 1523. https://doi.org/10.3390/nano11061523

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